Table 1.

Summary of middle molecules (n=59)

Removed by High Flux (<15 kD)Molecular Mass, kDRemoved by HDF (15–24.9 kD)Molecular Mass, kDNot Currently Removed (>25 kD)Molecular Mass, kD
Methionine-enkephalin0.5Clara cell protein15.8Hyaluronic acid25
Glutathione0.6Leptin16β-Trace protein26
Angiotensin A0.8Myoglobin17Soluble TNF receptor-127
δ–Sleep-inducing peptide0.8TNF-α17Adiponectin30
Dinucleoside polyphosphates1Soluble TNF receptor-217FGF-2332
Substance P1.3IL-1β17.5α1-Microglobulin33
Motilin2.7FGF-218VEGF34.2
Orexin B2.9IL-1018YKL-4040
Atrial natriuretic peptide3Retinol binding protein21.2Pentraxin-340.2
Desacylgherlin3.2Prolactin22α1-Acid glycoprotein43
Vasoactive interstinal peptide3.3κ-Ig light chain22.5AGEs45
Calcitonin3.4Complement factor D23.75λ-Ig light chain45
Gherlin3.4IL-1824Visfatin55
β-Endorphin3.4IL-624.5AOPPs>60
Orexin A3.5
Calcitonin gene–related peptide3.7
Cholecystokinin3.8
Endothelin4.2
Neuropeptide Y4.2
SIAM-14.2
Adrenomedullin5.7
Osteocalcin5.8
IGF-17.6
IL-88
Parathyroid hormone9.5
Guanylin10.3
β2-Microglobulin11.8
Uroguanylin12
Resistin12.5
Cystatin C13.3
Degranulation inhibiting proteina14.1
  • Thirty-one molecules had molecular mass under 15 kD, and therefore, they can be removed by high-flux dialysis. Fourteen molecules had molecular mass between 15 and 25 kD, and therefore, they can be removed by HDF. Fourteen molecules had molecular mass >25 kD. HDF, hemodiafiltration; FGF, fibroblast growth factor; VEGF, vascular endothelial growth factor; AGE, advanced glycosylation end product; AOPP, advanced oxidative protein products.

  • a Degranulation inhibiting protein corresponds to angiogenin.