Table 3.

Association between continuous serum bicarbonate and summary cognitive function domains in SPRINT MIND participants

Model 1, n=2853Model 2, n=2853Model 3, n=2804
DomainEstimate (SEM)P ValueEstimate (SEM)P ValueEstimate (SEM)P Value
Global cognitive function0.02 (0.005)<0.010.02 (0.006)<0.010.01 (0.006)0.01
Executive function0.02 (0.006)<0.010.02 (0.006)0.0040.02 (0.006)0.002
Memory0.01 (0.006)0.070.008 (0.006)0.200.006 (0.006)0.35
Attention/concentration0.01 (0.006)0.060.01 (0.006)0.040.01 (0.006)0.06
Language−0.008 (0.006)0.19−0.009 (0.006)0.15−0.009 (0.006)0.17
  • Model 1 adjusted for age, network, education, sex, and race. Model 2 adjusted for model 1 components as well as cardiovascular disease, systolic BP, use of diuretics, and antiacidosis medications (sodium bicarbonate, sodium citrate, citric acid/sodium citrate). Model 3 adjusted for model 2 components as well as eGFR and log-transformed urine albuminuria.