Table 2.

Associations of parathyroid hormone and nonoxidized parathyroid hormone concentrations with atherosclerotic events among 535 participants in the CArdiovascular and REnal outcomes in CKD stage 2-4 patients - the Fourth HOMburg evaluation

VariablePerson Years of FUN EventsUnadjusted AnalysisAdjustment for Kidney FunctionAdjustment for Kidney Function and Classic Cardiovascular Risk FactorsAdjustment for Kidney Function, Classic Cardiovascular Risk Factors, and CKD-Specific Risk Factors
116HR (95% CI)P ValueHR (95% CI)P ValueHR (95% CI)P ValueHR (95% CI)P Value
Continuous variables
 Log PTH22551164.23 (2.23 to 8.22)<0.0011.07 (0.50 to 2.26)0.871.00 (0.49 to 2.04)>0.991.02 (0.48 to 2.17)0.96
 Log nox-PTH22551163.60 (1.72 to 7.52)0.0011.16 (0.45 to 2.98)0.761.16 (0.46 to 2.94)0.751.17 (0.47 to 2.94)0.74
Categorized variables
 PTH
  First tertile (6–47 pg/ml)76628ReferenceReferenceReferenceReference
  Second tertile (48–78 pg/ml)783311.01 (0.61 to 1.69)0.960.79 (0.47 to 1.32)0.360.82 (0.48 to 1.40)0.470.85 (0.49 to 1.46)0.55
  Third tertile (79–543 pg/ml)683572.03 (1.29 to 3.20)0.0020.80 (0.46 to 1.38)0.420.78 (0.45 to 1.35)0.370.76 (0.43 to 1.34)0.34
 nox-PTH
  First tertile (3–7 pg/ml)77429ReferenceReferenceReferenceReference
  Second tertile (8–11 pg/ml)726291.07 (0.63 to 1.80)0.810.78 (0.46 to 1.34)0.370.74 (0.43 to 1.27)0.270.76 (0.44 to 1.33)0.34
  Third tertile (12–172 pg/ml)720582.12 (1.34 to 3.35)0.0011.04 (0.62 to 1.75)0.860.97 (0.58 to 1.65)0.921.03 (0.60 to 1.78)0.91
  • PTH, nox-PTH, and albuminuria have been log-transformed due to skewed distribution. Log: logarithm by the base 10, thus HRs per each ten-fold increase in PTH are presented. Adjustment for “kidney function” comprises eGFR and log albuminuria. Adjustment for “kidney function and classic cardiovascular risk factors” comprises eGFR, log albuminuria, age, sex, diabetes mellitus, body mass index, LDL cholesterol, and prevalent cardiovascular disease. Adjustment for “kidney function, classic cardiovascular risk factors, and CKD-specific risk factors” comprises eGFR, log albuminuria, age, sex, diabetes mellitus, body mass index, LDL cholesterol, prevalent cardiovascular disease, log–C-reactive protein, plasma albumin, plasma phosphate, plasma calcium, 25-OH-vitamin D3 levels, and log FGF-23. FU, follow-up; N, number of patients with atherosclerotic events; HR, hazard ratio; 95% CI, 95% confidence interval; PTH, parathyroid hormone; nox-PTH, nonoxidized PTH.