Table 2.

Performance on cognitive tests by categories of serum bicarbonate in SPRINT MIND participants

Serum Bicarbonate, mEq/L
Test≤24 (n=643)25–28 (n=1638)>28 (n=572)P Value
Screening battery
 Logical Memory Immediate Recall19.3 (4.9)19.4 (4.9)19.2 (4.8)0.80
 Montreal Cognitive Assessment23.3 (4.0)23.1 (4.1)22.6 (4.0)0.02
 Digit Symbol Coding51.5 (14.7)51.1 (15.0)50.6 (15.2)0.59
 Logical Memory Delayed Recall8.2 (3.3)8.3 (3.4)8.1 (3.3)0.36
Extended battery
 Hopkins Verbal Learning Test Learning Trials 1–321.5 (5.0)21.7 (5.3)21.7 (5.1)0.54
 Trail Making Test A43.3 (23.4)43.8 (25.2)42.7 (19.3)0.65
 Trail Making Test B122.3 (72.3)120.1 (71.0)121.0 (70.0)0.81
 Boston Naming Test11.9 (3.1)11.7 (3.2)11.6 (3.2)0.35
 Rey-Osterrieth Complex Figure14.3 (4.5)14.4 (4.7)14.3 (5.0)0.80
 Category Fluency – Animals18.1 (5.5)17.9 (5.0)17.6 (4.7)0.24
 Digit Span Total16.8 (4.2)16.9 (4.2)16.8 (3.9)0.57
 Hopkins Verbal Learning Test Delayed Recall5.7 (3.7)5.6 (3.9)5.2 (3.9)0.04
 Hopkins Verbal Learning Test Delayed Recognition10.7 (1.7)10.7 (1.6)10.7 (1.7)0.72
  • Values are expressed as mean (SD).