Table 2.

Correction rates and outcomes of hyponatremia reported in observational cohort studies

Author (Ref.), Year, Type of StudyNo. of Patients StudiedSerum Na, (mEq/L)CriteriaPatients with Osmotic Demyelination SyndromeΔNa With and Without Osmotic Demyelination Syndrome
Sterns (17), 1987, Retrospective two hospitals54≤110Admitted from home with chronica hyponatremia7 Clinical diagnosis>0.55b versus ≤0.55 mEq/L per hour P<0.02
Brunner et al. (43), 1990, Prospective single center13<115Admitted from home with hyponatremia3 MRI diagnosis30 versus 18 mEq/L per 24 h P<0.05
Tanneau et al. (45), 1994, Retrospective single center12≤115Admitted patients with compulsive water drinking5 Clinical diagnosis21.8 versus 15.5 mEq/L per 24 h P<0.02
Ellis (44), 1995, Prospective two hospitals158≤120All admitted patients9 Clinical examination by single neurologist12.1 versus 8.2 mEq/L per 24 h P=0.01
Sterns et al. (18), 1994, ¼ Prospective; ¾ Response to questionnaire multicenter64≤105All admitted patients11 Clinical diagnosis 3 MRI diagnosis All chronic casesa>12 versus ≤12 mEq/L per day P=0.02c>18 versus ≤18 mEq/L per 48 h P=0.02d>0.55b vs ≤0.55 mEq/L per hour P=0.01e
Vu et al. (46),  2009,  Retrospective  two hospitals255 ≤120Admitted from home  with hyponatremia4 MRI diagnosis>12 vs ≤12 mEq/L  per day P=0.06
(37 corrected by >12 mEq/L in 24 h)
  • Na, sodium; MRI, magnetic resonance imaging.

  • a Chronic defined as patients without psychotic polydipsia who became hyponatremic at home.

  • b Average rate of correction to 120 mEq/L.

  • c P<0.01 for patients with chronic hyponatremia.

  • d P=0.003 for patients with chronic hyponatremia.

  • e P=0.001 for patients with chronic hyponatremia.