Table 1.

Large single-center series of patients with osmotic demyelination (autopsy or magnetic resonance imaging)

Author (Ref.), Year; InstitutionYears of StudyTotal No. of PatientsPatients with HyponatremiaSerum Na in Patients with Hyponatremia Mean (Range), mEq/LDocumented Rapid CorrectionIncrease in Na in 24 h, mEq/LIncrease in Na in 48 h, mEq/L
Graff-Radford et al. (33), 2011; Mayo Clinic, the United States1999–20102418114 (96–129)16Not providedMedian, 21; range, 10–28
Odier et al. (34), 2010; University of Montreal, Canada1995–2007126106 (97–116)67, 10, 23, 15, 40, 2321, 28, 30, 19
Kallakatta et al. (35), 2011; Chitra Institute, India1999–20082520108 (91–130)12>8 mEq/L per dayNot provided
Menger and Paehge (37), 1999; University of Witten, Germany1990–19964421108 (99–121)21Mean 14.4Not provided
de Souza and Desai (38), 2012; Goa Medical College, India201088104 (95–122)89.9, 11.2, 22, 14, 13, 17, 14, 2016.5, 19, 27, 16,17, 28, 21, 31; from personal communication (A. de Souza)
Karp and Laureno (36), 1993; Washington Medical Center, the United States19931414104 (91–110)14>18 in 11 patients + 9 (23 in 35 h), 10, 12>18
  • Na, sodium.