Table 3.

Associations of plasma fibroblast growth factor 2 concentration with atherosclerosis progression

Model 1Model 2Model 3
VariablesOdds RatioP ValueOdds RatioP ValueOdds RatioP Value
FGF-2, per 50 pg/ml0.86 (0.76–0.96)0.0080.85 (0.75–0.95)<0.010.86 (0.76–0.96)0.02
 Hosmer–Lemeshow P value0.940.760.22
FGF-2 lowest tertile, 3–64 pg/mlReferenceReferenceReference
FGF-2 middle tertile, 65–119 pg/ml0.61 (0.37–0.99)0.050.65 (0.39–1.01)0.110.70 (0.40–1.20)0.20
FGF-2 highest tertile, 120–865 pg/ml0.42 (0.26–0.68)<0.0010.43 (0.26–0.72)0.0010.48 (0.28–0.82)<0.01
 Hosmer–Lemeshow P value1.000.190.69
  • First and second rows: model using levels of FGF-2 as a continuous variable. Third to sixth rows: model using levels of FGF-2 as tertiles. Model 1: unadjusted analysis; model 2: adjusted by age and sex; model 3: model 2 plus smoking status, diabetes, dyslipidemia, plaque presence at baseline, stage of CKD, intima-media thickness, body mass index, serum levels of glucose, total cholesterol, high-sensitivity C-reactive protein, 25-hydroxyvitamin D, and phosphate. All models included 431 patients (262 progressors and 169 nonprogressors). The lowest tertile of FGF-2 included 143 patients (102 progressors and 41 nonprogressors). The middle tertile of FGF-2 included 143 patients (86 progressors and 47 nonprogressors). The highest tertile of FGF-2 included 145 patients (74 progressors and 71 nonprogressors).