Table 4.

Association of serum bicarbonate with cognitive function domains in the SPRINT MIND MRI subgroup

Model 1, n=681Model 2, n=681Model 3, n=594
DomainEstimate (SEM)P ValueEstimate (SEM)P ValueEstimate (SEM)P Value
Global cognitive function0.0391 (0.01)0.0010.0358 (0.01)0.0030.0328 (0.01)0.01
Executive function0.0304 (0.01)0.020.0246 (0.01)0.060.0246 (0.01)0.07
Memory0.0255 (0.01)0.050.0256 (0.01)0.050.0203 (0.01)0.14
Attention/concentration0.0240 (0.01)0.070.0196 (0.01)0.150.0164 (0.01)0.26
Language0.0024 (0.01)0.86−0.0005 (0.01)0.970.0078 (0.01)0.59
  • Model 1 adjusted for age, network, education, sex, race, cardiovascular disease, systolic BP, use of diuretics and antiacidosis medications (sodium bicarbonate, sodium citrate, citric acid/sodium citrate), eGFR, and log-transformed urine albuminuria. Model 2 adjusted for model 1 components as well as scanner type, intracranial volume, and total abnormal volume. Model 3 adjusted for model 2 components as well as vascular reactivity and cerebral blood flow.