Table 3.

Primary outcome of rate of rt-PA use for treatment of catheter malfunction

VariablePre PeriodPost Period
Total number of dialysis sessions with use of rt-PA for treatment of catheter malfunction1068407
Total catheter days58,05040,430
rt-PA use days per 1000 catheter days18.4010.07
Unadjusted incidence rate ratio for post versus pre rate of outcome (95% confidence interval)0.33 (0.24 to 0.44)a
Adjusted incidence rate ratio for post versus pre rate of outcome (95% confidence interval)0.39 (0.30 to 0.52)a,b
  • rt-PA, recombinant tissue plasminogen activator.

  • a From a three-level mixed effects negative binomial regression model, with enrollment nested within person and person nested within site. Person and site were treated as random effects.

  • b Adjusted for age, sex, inclusion criteria, prior rate of catheter replacement, duration on dialysis, stroke, and history of deep venous thrombosis/pulmonary embolism.