Table 1.

Clinical and histopathologic characteristics at diagnosis according to the presence or absence of mesangial C4d deposits in the kidney biopsy

VariablesAll, n=190C4d+, n=38C4d−, n=152
Age, yr, mean±SD29±1428±1629±19
Men (%)123 (65)24 (63)99 (65)
Body mass index, kg/m2, median [IQR]21.8 [19.6–22.9]21.9 [19.8–23.7]21.7 [19–23.1]
Smoker, n (%)38 (20)8 (21)30 (20)
Macroscopic hematuria, n (%)81 (43)16 (42)65 (43)
Systolic BP, mm Hg, mean±SD121±13120±13119±16
Diastolic BP, mm Hg, mean±SD68±1071±1076±10
Hypertension, n (%)24 (13)6 (16)18 (12)
Serum creatinine, mg/dl, median [IQR]1.0 [0.8–1.0]1.0 [0.8–1.1]1.0 [0.9–1.1]
eGFR, ml/min per 1.73 m2, median [IQR]100 [86–112]98 [88–110]99 [89–115]
eGFR categories, n (%)
 81–9043 (23)9 (24)34 (22)
 91–10095 (50)18 (47)77 (51)
 >10052 (27)11 (29)41 (27)
Protein-to-creatinine ratio, g/g, median [IQR]a18 [0.8–3.9]1.9 [0.9–3.1]1.5 [0.9–2.2]
Histopathologic Oxford classification, n (%)
 M157 (30)15 (39)42 (28)
 S122 (12)6 (16)16 (11)
 E119 (10)5 (13)14 (9)
Interstitial fibrosis
 T0: <25%133 (70)23 (61)110 (72)
 T1: 25%–50%40 (21)12 (32)28 (18)
 T2: >50%17 (9)3 (8)14 (9)
Glomeruli with crescents median [IQR]1.1 [0–2]1.5 [0–4]1.3 [0–2]
  • IQR, interquartile range; M, mesangial cellularity; S, segmental sclerosis; E, endocapillary hypercellularity; T, interstitial fibrosis and tubular atrophy.

  • a For protein-to-creatinine ratio (grams per gram) median [IQR], the P value among all variables was statistically significant at P=0.04.