Table 5.

Extended duration nocturnal hemodialysis and change in select established uremic retention solutes

MetaboliteNocturnal HD Final-to-Baseline Metabolite Ratio ±SDP ValueConventional HD Final-to-Baseline Metabolite Ratio ±SDP Value
p-Cresol sulfate1.02±0.120.351.14±0.660.84
Indoxyl sulfate1.10±0.430.901.16±0.730.99
Trimethylamine N-oxide1.07±0.550.711.13±0.490.82
Symmetric dimethylarginine1.28±0.300.230.87±0.270.99
Asymmetric dimethylarginine1.08±0.190.940.96±0.160.73
Uridine0.98±0.410.291.01±0.480.87
Sorbitol1.45±1.340.591.56±1.210.84
Orotate1.05±0.360.680.90±0.380.73
Uracil1.03±0.720.231.40±1.120.87
Cytidine1.27±1.010.991.26±0.850.84
Kynurenic acid1.24±0.560.191.07±0.440.92
Hypoxanthine1.07±0.500.901.05±0.500.93
Thymine1.02±0.320.500.98±0.250.91
Anthranilic acid1.11±0.460.901.21±0.730.91
Urate0.99±0.150.451.00±0.160.99
Hippurate2.52±6.380.461.63±1.970.92
Xanthine1.07±0.530.071.02±0.510.73
Kynurenine1.07±0.340.440.93±0.310.73
Quinolinate0.99±0.360.631.02±0.520.84
Oxalate1.17±0.460.270.93±0.340.73
Xanthosine1.35±0.680.071.08±0.280.73
Oleoylcarnitine1.04±0.600.281.10±0.470.99
Linoleylcarnitine1.00±0.670141.00±0.320.92
Palmitoylcarnitine1.01±0.440.281.01±0.310.93
Stearoylcarnitine1.27±0.850.880.92±0.380.92
  • Final-to-baseline metabolite ratio denotes the mean final 1-year metabolite level-to-initial baseline metabolite level ratio. P values are calculated using the Wilcoxon rank sum test comparing metabolite level at baseline versus 1 year after multiple testing corrections (false discovery rate <0.05). Nocturnal HD, in-center extended duration nocturnal hemodialysis; conventional HD, standard duration conventional hemodialysis.