Table 3.

Metabolites that significantly decreased after 1 year of extended duration nocturnal hemodialysis

MetaboliteNocturnal HD Final-to-Baseline Metabolite Ratio ±SDP ValueConventional HD Final-to-Baseline Metabolite Ratio ±SDP Value
l-carnitine0.82±0.270.0031.02±0.220.99
Acetylcarnitine0.75±0.300.0031.10±0.310.92
α-Glycerophosphate0.78±0.50<0.011.32±0.820.80
Phosphocreatine0.95±1.730.0032.24±2.680.75
Pentose monophosphate0.81±0.850.011.40±1.530.96
Octanoylcarnitine0.84±0.430.021.11±0.530.96
Hexanoylcarnitine0.87±0.530.031.06±0.530.88
Creatinine0.95±0.170.040.98±0.220.98
  • Final-to-baseline metabolite ratio denotes the mean final 1-year metabolite level-to-initial baseline metabolite level ratio. P values are calculated using the Wilcoxon rank sum test comparing metabolite level at baseline versus 1 year after multiple testing corrections (false discovery rate <0.05). Nocturnal HD, in-center extended duration nocturnal hemodialysis; conventional HD, standard duration conventional hemodialysis.