Table 6.

Prognostic significance of clinical and histopathologic parameters on ESRD

VariableUnivariable AnalysisMultivariable AnalysisaMultivariable Analysisb
HR (95% CI)P ValueHR (95% CI)P ValueHR (95% CI)P Value
Age, yr1.02 (1.01 to 1.03)<0.011.01 (1.00 to 1.03)0.06
Males1.19 (0.77 to 1.84)0.44
Lung involvement1.19 (0.75 to 1.88)0.47
Double positivity1.07 (0.64 to 1.78)0.80
Serum creatinine at presentation ≥5.7 mg/dl4.83 (2.75 to 8.47)<0.0011.98 (0.96 to 4.10)0.07
Dialysis dependency at presentation6.50 (3.68 to 11.47)<0.001aa3.2 (1.6 to 6.3)0.001
Histopathologic classification<0.010.15
 Focal (reference)
 Crescentic20.29 (2.80 to 147.26)8.38 (1.10 to 63.87)
 Mixed11.67 (1.54 to 88.47)6.77 (0.87 to 52.65)
 Sclerotic25.72 (3.24 to 204.51)11.17 (1.34 to 3.13)
Percentage normal glomeruli0.95 (0.93 to 0.98)<0.0010.97 (0.95 to 0.99)<0.010.97 (0.95 to 0.99)0.01
Percentage cellular crescents1.02 (1.01 to 1.02)<0.0011.02 (1.00 to 1.05)0.09
Percentage globally Sclerotic glomeruli1.01 (1.00 to 1.02)0.20
Interstitial fibrosis and tubular atrophy, score 2–31.88 (1.20 to 2.95)<0.011.38 (0.87 to 2.18)0.17
Interstitial infiltrate, score 2–32.35 (1.44 to 3.83)0.0011.90 (1.16 to 3.13)0.012.02 (1.2 to 3.5)0.01
Tubulitis, present1.51 (0.96 to 2.35)0.07
  • HR, hazard ratio; 95% CI, 95% confidence interval.

  • a Each parameter that was significant in univariable analysis, was analyzed in a multivariable analysis including dialysis dependency at presentation. Dialysis dependency at presentation remained significant in each multivariable analysis with P values ≤0.002.

  • b Parameters that were significant in the multivariable analysisa were included in this multivariate analysis.