Table 3.

Characteristics stratified by histopathologic class: Baseline and follow-up characteristics

CharacteristicFocal (n=15)Crescentic (n=72)Mixed (n=26)Sclerotic (n=10)P Value
Age, yr41±1953±1953±1650±250.17
Males9 (60)41 (57)10 (39)6 (60)0.37
Anti-GBM antibodies  positivea11 (79)58 (91)17 (71)6 (60)0.02
 Anti-GBM antibodies, ANCA negative7 (64)37 (67)9 (53)0 (0)0.03
 Anti-GBM antibodies, ANCA positive4 (36)18 (33)8 (47)5 (100)
ANCA typeb0.001
 Anti-MPO0 (0)14 (100)7 (87)2 (100)
 Anti-PR33 (100)0 (0)1 (13)0 (0)
Lung involvementc7 (50)26 (37)4 (16)4 (57)0.06
Serum creatinine at presentation, mg/dl1.4 (1.0–1.7)7.8 (6.4–12.6)4.2 (2.6–7.2)6.6 (4.5–15.2)<0.001
Dialysis dependent at presentation0 (0)51 (71)10 (39)8 (80)<0.001
Year of diagnosis
 1986–20003 (20)28 (39)4 (15)6 (60)<0.01
 2001–20062 (13)26 (36)8 (31)2 (20)
 2007–201510 (67)18 (25)14 (54)2 (20)
Duration of follow-up, yr4.7±3.74.9±4.24.3±3.83.4±3.60.72
ESRD at end of follow-up1 (7)57 (79)15 (58)9 (90)<0.001
Transplantation0 (0)25 (35)4 (15)3 (30)0.01
Death2 (13)24 (33)5 (19)3 (30)0.32
  • Data are number (%), mean±SD, or median (interquartile range). GBM, glomerular basement membrane; MPO, myeloperoxidase; PR3, proteinase 3.

  • a Results from anti-GBM antibody ELISA were available in 112 patients. Results from ANCA ELISA were available in 114 patients. Both tests were performed in 108 patients.

  • b Thirty-five patients were anti-GBM antibodies and ANCA positive. Of these, ANCA type (anti-MPO or anti-PR3) was known in 27 patients.

  • c Total, n=117 patients.