Table 4.

Relationship between plasma FGF23 and left ventricular hypertrophy stratified by level of GFR

ModelRelative Odds of Left Ventricular Hypertrophy (95% Confidence Interval)
GFR≥45 ml/min per 1.73 m2GFR<45 ml/min per 1.73 m2
Model 1
 FGF23, RU/ml
  <100ReferenceReference
  100–1692.22 (0.94 to 5.25)1.26 (0.46 to 3.47)
  ≥1703.17 (1.22 to 8.22)a1.21 (0.46 to 3.16)
 FGF23, per doubling1.91 (1.32 to 2.77)b1.03 (0.76 to 1.39)
Model 2
 FGF23, RU/ml
  <100ReferenceReference
  100–1691.98 (0.77 to 5.09)0.74 (0.24 to 2.26)
  ≥1703.18 (1.16 to 8.77)a0.75 (0.27 to 2.11)
 FGF23, per doubling2.10 (1.38 to 3.17)b0.86 (0.60 to 1.24)
Model 3
 FGF23, RU/ml
  <100ReferenceReference
  100–1692.02 (0.73 to 5.55)0.44 (0.13 to 1.50)
  ≥1703.08 (1.02 to 9.24)a0.39 (0.12 to 1.28)
 FGF23, per doubling2.02 (1.29 to 3.17)c0.68 (0.44 to 1.06)
  • Model 1: unadjusted. Model 2: additionally adjusted for age, sex, race, and body mass index. Model 3: additionally adjusted for systolic BP z-score, hemoglobin z-score, and use of angiotensin-converting enzyme inhibitors or angiotensin-receptor blockers. FGF23, fibroblast growth factor 23.

  • a P<0.05.

  • b P<0.001.

  • c P<0.01.