Table 3.

Relationship between FGF23 and left ventricular mass

ModelRelative Odds of Left Ventricular Hypertrophy (95% Confidence Interval)Mean LVMI z-Score (95% Confidence Interval)
Model 1
 FGF23, RU/ml
  <100ReferenceReference
  100–1691.98 (1.04 to 3.79)a0.30 (0.06 to 0.54)a
  ≥1702.41 (1.25 to 4.62)b0.29 (0.04 to 0.55)a
 FGF23, per doubling1.38 (1.12 to 1.71)b0.14 (0.04 to 0.23)b
Model 2
 FGF23, RU/ml
  <100ReferenceReference
  100–1691.78 (0.90 to 3.52)0.30 (0.07 to 0.54)a
  ≥1702.53 (1.28 to 4.97)b0.32 (0.07 to 0.57)a
 FGF23, per doubling1.43 (1.13 to 1.81)b0.14 (0.04 to 0.23)b
Model 3
 FGF23, RU/ml
  <100ReferenceReference
  100–1691.31 (0.62 to 2.77)0.15 (−0.09 to 0.40)
  ≥1701.44 (0.66 to 3.17)−0.02 (−0.29 to 0.25)
 FGF23, per doubling1.13 (0.85 to 1.50)0.01 (−0.10 to 0.11)
  • Model 1: unadjusted. Model 2: additionally adjusted for age, sex, race, and body mass index. Model 3: additionally adjusted for systolic BP z-score, hemoglobin z-score, use of angiotensin-converting enzyme inhibitors or angiotensin-receptor blockers, and eGFR. FGF23, fibroblast growth factor 23; LVMI, left ventricular mass index.

  • a P<0.05.

  • b P<0.01.