Table 1.

Studies examining corticosteroid therapy in acute interstitial nephritis

Author, Yr (ref)Sample sizePeak SCr, mg/dlFinal SCr, mg/dlFollow-Up, MoComment
SteroidNo SteroidSteroidNo SteroidSteroidNo Steroid
Clarkson et al. 2004 (4)26167. received steroids late after diagnosis (median delay >3 wk).
González et al. 2008 (5)5295. treated patients with complete recovery had shorter delay to steroids (13 d) as compared with those without complete recovery (34 d).
Raza et al. 2012 (7)37126. GFR with steroid versus control (P<0.05). No difference in kidney outcomes on the basis of steroid timing.
Muriithi et al. 2014 (6)83123. patients had superior kidney outcomes with early versus late steroid therapy.
Valluri et al. 2015 (8)73514.033.16NRNR12Worse kidney function in steroid-treated versus control at biopsy (SCr 4.2 versus 3.3 mg/dl). Steroid-treated patients had complete recovery (48%) versus control group (41%); final SCr not different at 1 yr.
Prendecki et al. 2016 (9)1582920.5 ml/min (eGFR)25 ml/min (eGFR)43 ml/min (eGFR)24 ml/min (eGFR)24Steroid-treated patient had better eGFR at 2 yr and less dialysis (5.1% versus 24.1%). Dose, duration, and time to steroid initiation were variable.
  • SCr, serum creatinine concentration; NR, not reported.