Table 3.

Cox regression analysis for incident ESRD according to baseline variables among 402 patients with kidney biopsies

VariablesUnivariableMultivariable
HR (95% CI)P ValueHR (95% CI)P Value
Age, yr1.01 (0.99 to 1.03)0.23
Sex1.50 (0.91 to 2.48)0.12
Systolic BP, >140 mmHg1.03 (1.02 to 1.04)<0.0011.00 (0.99 to 1.02)0.68
eGFR, ≥15 ml/min per 1.73 m20.96 (0.95 to 0.97)<0.0010.98 (0.97 to 0.99)<0.001
Disease type<0.001<0.001
 IgAN1.0 (Reference)1.0 (Reference)
 IMN0.54 (0.13 to 0.98)0.0010.15 (0.03 to 0.70)0.02
 DN3.61 (1.75 to 5.42)0.0013.13 (1.59 to 6.18)0.001
 Focal segmental GN3.32 (1.26 to 10.23)0.022.10 (0.56 to 7.85)0.27
Serum albumin, g/dl1.02 (0.99 to 1.05)0.16
Log10 urine protein3.36 (1.83 to 6.12)<0.0012.63 (1.36 to 6.45)0.002
Log10 urinary fibrinogen to Cr2.72 (1.91 to 3.87)<0.0012.12 (1.31 to 3.26)0.003
IFTA3.41 (2.47 to 4.72)<0.0011.76 (1.22 to 2.52)0.002
Global sclerosis1.19 (1.00 to 1.43)0.06
Segmental sclerosis1.10 (0.55 to 2.20)0.80
  • HR, hazard ratio; 95% CI, 95% confidence interval; IgAN, IgA nephropathy; IMN, idiopathic membranous nephropathy; DN, diabetic nephropathy; Cr, creatinine; IFTA, interstitial fibrosis and tubular atrophy.