Table 1.

Baseline characteristics of the randomized patients

VariablesAll, n=78Placebo, n=39Sevelamer, n=39
Age, yr63±1363±1463±13
Men, n (%)55 (71)28 (72)27 (69)
Body mass index, kg/m228±528±528±5
GFR MDRD, ml/min per 1.73 m227±928±1025±8
SBP, mmHg142±20143±20141±20
DBP, mmHg79±1080±1078±10
Serum C-terminal FGF23, RU/ml157 (120–241)142 (120–221)166 (120–249)
Serum intact FGF23, pg/ml72 (47–103)71 (42–118)72 (53–109)
Serum α-klotho, pg/ml809 (674–981)784 (648–1060)830 (714–927)
Serum phosphorus, mg/dl3.8±0.53.9±0.53.8±0.6
Serum calcium, mg/dl9.4±0.49.3±0.49.4±0.4
Serum creatinine, mg/dl2.6±0.92.6±0.82.7±0.9
Serum intact PTH, pg/ml97 (61–127)103 (71–141)91 (58–123)
Serum 25 hydroxyvitamin D, ng/ml31±1229±1134±18
Serum 1,25 dihydroxyvitamin D, ng/ml28 (22–40)31 (23–39)26 (20–42)
CRP, mg/L3 (2–8)3 (2–4)5 (3–10)
Serum triglycerides, mg/dl137 (93–200)151 (97–256)136 (89–163)
Serum total cholesterol, mg/dl182±42183±39179±45
Serum HDL cholesterol, mg/dl54±1953±2054±19
Serum LDL cholesterol, mg/dl96±3992±3999±40
Serum hemoglobin, g/dl12.6±1.412.5±1.312.7±1.5
Urinary phosphate-to-urinary creatinine ratio, mmol/mmol2.0±0.62.0±0.52.0±0.7
Urinary calcium-to-urinary creatinine ratio, mmol/mmol0.1±0.10.1±0.10.1±0.1
Urinary creatinine, mmol/L5.8±2.25.4±1.86.2±2.5
  • Data are quoted as the mean±SD for normally distributed variables, the median (interquartile range) for non-normally distributed variables, or the number (percentage) for binary variables. GFR MDRD, GFR calculated with the Modification of Diet in Renal Disease formula; SBP, systolic BP; DBP, diastolic BP; FGF23, fibroblast growth factor 23; RU, relative units; PTH, parathyroid hormone; CRP, C-reactive protein.