Table 1.

Baseline characteristics of African-American Study of Kidney Disease and Hypertension participants without baseline proteinuria, by APOL1 risk allele status

CharacteristicAll (n=480)APOL1 Low-Risk (n=398)APOL1 High-Risk (n=82)P Value
Age at randomization, yr56±1056±1055±100.56
Female194 (40)162 (41)32 (39)0.81
European ancestry, %16.6±13.717.1±14.114.2±11.40.05
Current smoker131 (27)108 (27)23 (28%)0.89
Systolic BP, mm Hg148±24150±25139±19<0.01
Body mass index, kg/m230.7±6.630.6±6.431.1±7.40.62
Baseline eGFR, ml/min per 1.73 m253±1353±1450±120.02
Total cholesterol, mg/dl211±43211±44211±370.91
HDL, mg/dl48±1649±1648±130.70
Serum albumin, g/dl4.3±0.34.3±0.34.4±0.30.09
Median urine protein, g/g Cr0.04 (0.02–0.08)0.04 (0.02–0.08)0.04 (0.02–0.09)0.43
Mean urine protein, g/g Cr0.06±0.050.06±0.050.06±0.050.55
Urine sodium, g/d3.4 (2.2–4.5)3.4 (2.2–4.6)3.1 (2.1–4.4)0.72
Randomized BP goal0.72
 Low243 (51)203 (51)40 (49)
 Usual237 (49)195 (49)42 (51)
Randomized BP drug0.67
 Metoprolol191 (40)158 (40)33 (40)
 Ramipril198 (41)167 (42)31 (38)
 Amlodipine91 (19)73 (18)18 (22)
  • Values presented as mean±SD, median (interquartile range), or n (%). APOL1 high-risk defined as having 2 risk alleles and low-risk defined as having 0–1 risk alleles.