Table 3.

Annual eGFR decline by APOL1 risk status, overall and stratified by onset of proteinuria, in the African-American Study of Kidney Disease and Hypertension

ModelAnnual eGFR DeclineDifference in Annual eGFR Decline for APOL1 High-Risk versus Low-RiskP-interactiona
APOL1 Low-Risk (95% Confidence Interval)APOL1 High-Risk (95% Confidence Interval)
Overall (n=480)−1.11 (−1.32 to −0.90)−1.65 (−2.05 to −1.25)−0.54 (−0.95 to −0.13)0.01
Before incident proteinuria (n=480)−0.47 (−0.68 to −0.26)−0.52 (−0.96 to −0.09)−0.06 (−0.50 to 0.38)0.80
After incident proteinuria (n=254)−2.44 (−2.89 to −1.98)−2.67 (−3.47 to −1.91)−0.25 (−1.08 to 0.58)0.54
  • Models adjusted age at randomization, sex, percentage of European ancestry, baseline systolic BP, log-transformed baseline proteinuria, and randomized treatment groups. eGFR in ml/min per 1.73 m2.

  • a P value for interaction term between time (in years) and APOL1 risk status (high- versus low-risk).