Table 2.

Percent difference in eGFRcys at Coronary Artery Risk Development in Young Adults Study year 10 (calendar years, 1995–1996) among participants with cumulative marijuana use (in marijuana-years) compared with never-users

Cumulative Marijuana Use at Yr 10 (Marijuana-Yr)Participants (n)eGFRcys, mean (SD)UnadjustedMultivariable-Adjusted
% Difference eGFRcys (95% CI)P Valuea% Difference eGFRcys (95% CI)P Valuea
Overall cohort
 Never used634111 (13)ReferentReferent
 >0–<0.51744111 (13)0.0 (−1.2 to 1.3)0.970.2 (−1.1 to 1.4)0.79
 0.5–<2930111 (13)−0.2 (−1.6 to 1.2)0.741.0 (−0.5 to 2.5)0.18
 2–<5330110 (14)−0.8 (−2.6 to 1.1)0.420.3 (−1.6 to 2.2)0.77
 ≥5127108 (15)−3.2 (−5.7 to −0.6)0.02b−3.0 (−5.6 to −0.4)0.03b
P value trendc<0.01b0.04b
Raced
 White
  Never used284110 (12)ReferentReferent
  >0–<0.5931110 (12)−0.5 (−2.3 to 1.3)0.56−0.9 (−2.7 to 0.8)0.30
  0.5–<2514109 (12)−1.3 (−3.2 to 0.7)0.20−0.5 (−2.5 to 1.5)0.61
  2–<5136108 (13)−2.5 (−5.2 to 0.3)0.08−1.9 (−4.5 to 0.9)0.19
  ≥578104 (15)−6.1 (−9.3 to −2.8)<0.001b−6.0 (−9.2 to −2.7)<0.001b
  P value trendc<0.001b<0.001b
 Black
  Never used350112 (14)ReferentReferent
  >0–<0.5813113 (14)0.9 (−0.8 to 2.7)0.301.0 (−0.6 to 2.7)0.22
  0.5–<2416113 (14)1.2 (−0.8 to 3.2)0.252.5 (0.5 to 4.6)0.02b
  2–<5194112 (15)0.2 (−2.2 to 2.7)0.852.1 (−0.4 to 4.6)0.10
  ≥549113 (12)1.5 (−2.6 to 5.8)0.481.0 (−3.1 to 5.2)0.64
  P value trendc0.600.51
  • Multivariable model adjusted for age, race, sex, study site, income, education, employment, systolic BP, diastolic BP, diabetes, hyperlipidemia, body mass index, physical activity, and cumulative years of tobacco smoking, heavy and binge alcohol use, and cocaine, amphetamine, and heroin use. The results can be interpreted as the percent difference in eGFRcys at year 10 compared with the referent category. For example, in the multivariable-adjusted model, compared with participants who never used marijuana, those with ≥5 marijuana-years of use had a 3.0% lower eGFRcys, and this difference was statistically significant (P=0.03). eGFRcys, eGFR as calculated with the Chronic Kidney Disease Epidemiology Collaboration cystatin C equation (ml/min per 1.73 m2); 95% CI, 95% confidence interval.

  • a P values for percent difference in eGFRcys compared with the referent (never use).

  • b P values <0.05.

  • c P values for test for trend across categories of marijuana use.

  • d P value for test for interaction by race=0.03.