Table 3.

Percent difference in eGFRcys change per year during Coronary Artery Risk Development in Young Adults Study years 10–15 (calendar years, 1995–1996 to 2000–2001) and 15–20 (calendar years, 2000–2001 to 2005–2006) among participants with cumulative marijuana use (in marijuana-years) compared with never-users

Cumulative Marijuana Use (Marijuana-Yr)a5-Yr Person-Intervals (n)eGFRcys Change per Yr, Mean (SD)UnadjustedMultivariable-Adjusted
% Difference eGFRcys (95% CI)P Valueb% Difference eGFRcys (95% CI)P Valueb
Never used995−0.7 (4.3)ReferentReferent
>0–<0.52709−0.6 (6.8)−0.1 (−0.4 to 0.1)0.33−0.2 (−0.5 to 0.1)0.16
0.5–<21411−0.8 (2.1)−0.1 (−0.4 to 0.2)0.57−0.2 (−0.5 to 0.1)0.25
2–<5462−0.6 (2.3)−0.1 (−0.4 to 0.3)0.79−0.1 (−0.6 to 0.3)0.58
≥5238−0.9 (2.2)−0.2 (−0.7 to 0.4)0.52−0.1 (−0.7 to 0.5)0.72
P value trendc0.630.82
  • Multivariable model adjusted for age, race, sex, study site, income, education, employment, systolic BP, diastolic BP, diabetes, hyperlipidemia, body mass index, physical activity, and cumulative years of tobacco smoking, heavy and binge alcohol use, and cocaine, amphetamine, and heroin use. The results can be interpreted as the percent difference in change in eGFRcys per year during years 10–15 and 15–20 compared with the referent category. For example, in the multivariable-adjusted model, compared with participants who never used marijuana, the annualized change in eGFRcys relative to the value at the beginning of each 5-yr interval was smaller by 0.1% per year among those with ≥5 marijuana-years of use, but this difference was not statistically significant (P=0.72). CARDIA, Coronary Artery Risk Development in Young Adults; eGFRcys, estimated glomerular filtration rate as calculated with the Chronic Kidney Disease Epidemiology Collaboration cystatin C equation (ml/min per 1.73 m2); 95% CI, 95% confidence interval.

  • a Cumulative marijuana use was evaluated at CARDIA years 10 (calendar years, 1995–1996) and 15 (calendar years, 2000–2001).

  • b P values for percent difference in eGFRcys change per year compared with the referent (never use).

  • c P values for test for trend across categories of marijuana use.