Table 3.

Univariate and multivariable logistic regression models predicting sustained virologic response

Baseline Predictors of Sustained Virologic ResponseUnivariate ModelMultivariable Model 1Multivariable Model 2
Odds Ratio (95% CI)P ValueOdds Ratio (95% CI)P ValueOdds Ratio (95% CI)P Value
Age, per 10 yr1.37 (0.75 to 2.5)0.301.08 (0.48 to 2.5)0.85
Sex, men versus women1.30 (0.41 to 4.1)0.452.25 (0.51 to 10)0.28
Race, white versus nonwhite1.48 (0.53 to 4.1)0.452.0 (0.54 to 7.6)0.30
Diabetes versus nondiabetic0.64 (0.23 to 1.8)0.38
Cirrhosis versus noncirrhotic0.61 (0.22 to 1.7)0.340.71 (0.21 to 2.4)0.59
HIV coinfection2.02 (0.24 to 17.3)0.51
Genotypes 2–4 (compared with genotype 1)0.50 (0.17 to 1.5)0.210.49 (0.13 to 1.8)0.28
Ribavirin use0.69 (0.26 to 1.8)0.47
Prior transplant1.06 (0.36 to 3.1)0.91
Prior treatment failure0.38 (0.13 to 1.1)0.080.27 (0.08 to 0.97)0.050.33 (0.11 to 1.1)0.07
Baseline eGFR, per 10 ml/min decrease in eGFR1.64 (1.3 to 2.2)<0.0011.70 (1.2 to 2.3)0.0011.68 (1.3 to 2.2)<0.001
  • Model 1 includes demographics and a priori clinical predictors known to be associated with decreased sustained virologic response, cure of HCV. Model 2 includes only those variables with P values <0.20 in the univariate model. 95% CI, 95% confidence interval; —, not applicable.