Table 3.

Patient characteristics on the basis of ANCA specificity (MPO-ANCA, PR3-ANCA) of an inception cohort of patients with ANCA vasculitis with high-frequency renal involvement evaluated at the University of North Carolina Kidney Center (excluding patients with eosinophilic granulomatosis with polyangiitis). The proportion of patients with each characteristic (other than age) is expressed as a percent of all ANCA disease patients, MPO-ANCA disease patients and PR3-ANCA disease patients.

CharacteristicAll n=502MPO-ANCA n=283PR3-ANCA n=219Pa Value MPO versus PR3
Age at diagnosis<0.001
 Mean±SD55.8±19.159.2±17.651.5±20.0
 Median (IQR)60 (46, 71)64 (50, 72)56 (38, 67)
CHCC<0.001
 RLV121 (24.1%)98 (34.6%)23 (10.5%)
 MPA264 (52.6%)155 (54.8%)109 (49.8%)
 GPA117 (23.3%)30 (10.6%)87 (39.7%)
Kidney involvement488 (97%)282 (99.7%)206 (94.1%)0.001
Lung involvement252 (50%)117 (41.3%)135 (61.6%)<0.001
ENT involvement185 (37%)67 (23.7%)118 (53.9%)<0.001
  • The proportion of patients with each characteristic (other than age) is expressed as a percent of all ANCA disease patients, MPO-ANCA disease patients and PR3-ANCA disease patients. Other characteristics of this cohort were published by Lionaki et al. (5). MPO-ANCA, ANCA specific for myeloperoxidase; PR3-ANCA, ANCA specific for proteinase 3; MPO, myeloperoxidase; PR3, proteinase 3; IQR, interquartile range; CHCC, 2012 Chapel Hill Consensus Conference Vasculitis Nomenclature; RLV, renal-limited vasculitis; MPA, microscopic polyangiitis; GPA, granulomatosis with polyangiitis; ENT, ear nose and throat.

  • a P values are calculated using Fisher’s exact test for categoric variables and Wilcoxon two-sample test for continuous variables.