Table 2.

Patient characteristics on the basis of clinicopathologic phenotype (RLV, MPA, GPA) of an inception cohort of patients with ANCA vasculitis with high-frequency renal involvement evaluated at the University of North Carolina Kidney Center (excluding patients with eosinophilic granulomatosis with polyangiitis). The proportion of patients with each characteristic (other than age) is expressed as a percent of RLV patients, MPA patients and GPA patients.

CharacteristicRLV n=121MPA n=264GPA n=117P Valuea RLV versus MPA versus GPAP Valuea RLV versus MPA/GPAP Valuea MPA versus GPA
Diagnosis age<0.001<0.01<0.001
 Mean±SD59.8±18.457.5±18.147.9±19.8
 Median (IQR)66 (50, 73)61 (49, 71)50 (32, 64)
MPO/PR3<0.001<0.001<0.001
 MPO98 (81.0%)155 (58.7%)30 (25.6%)
 PR323 (19.0%)109 (41.3%)87 (74.4%)
Kidney involvement121 (100%)262 (99.2%)105 (89.7%)<0.001<0.03<0.001
Lung involvement0 (0%)157 (59.5%)95 (81.2%)<0.001NA<0.001
ENT involvement0 (0%)97 (36.7%)88 (75.2%)<0.001NA<0.001
  • The proportion of patients with each characteristic (other than age) is expressed as a percent of RLV patients, MPA patients and GPA patients. Other characteristics of this cohort were published by Lionaki et al. (5). (MPA/GPA = all patients with MPA and with GPA combined.) RLV, renal-limited vasculitis; MPA, microscopic polyangiitis; GPA, granulomatosis with polyangiitis; IQR, interquartile range; PR3, proteinase 3; NA, not aplicable becuase by definition RLV patients do not have lung or ENT involvement.; ENT, ear, nose and throat.

  • a P values are calculated using Fisher’s exact test for categoric variables and Wilcoxon two-sample test for continuous variables.