Table 4.

Associations of baseline fibroblast growth factor 23 concentrations with annualized percentage change in height-adjusted total kidney volume in the HALT-PKD Study A

Mean Annualized Percentage Change in HtTKV (95% CI)P Value Trend
Unadjusted
 FGF23 quartile 15.96 (5.49 to 6.44)0.01
 FGF23 quartile 25.63 (4.50 to 6.78)
 FGF23 quartile 36.20 (5.06 to 7.36)
 FGF23 quartile 46.67 (5.52 to 7.84)
Adjusteda
 FGF23 quartile 16.04 (5.55 to 6.54)0.03
 FGF23 quartile 25.78 (4.61 to 6.96)
 FGF23 quartile 36.10 (4.92 to 7.30)
 FGF23 quartile 46.76 (5.57 to 7.96)
  • HtTKV, height adjusted total kidney volume; 95% CI, 95% confidence interval; FGF23, fibroblast growth factor 23.

  • a Adjusted by age, sex, body mass index, systolic BP, randomization group, calcium, phosphorus, eGFR, urinary albumin excretion, and polycystic kidney disease genotype.