Table 1.

Baseline characteristics of the study cohort overall and by eGFR

CharacteristiceGFR, ml/min per 1.73 m2Total, n=1,139,470
eGFR≥105, n=357,687eGFR=90–104, n=346,623eGFR=60–89, n=365,491eGFR=30–59, n=63,805eGFR<30, n=5864
eGFR, ml/min per 1.73 m2, mean±SD117±997±479±850±823±694±21
Age, yr, mean±SD34±1051±1363±1578±1179±1452±18
Women, no. (%)189,998 (53)170,910 (49)200,540 (55)39,151 (61)3219 (55)603,818 (53)
Recent or current use of medications, no. (%)
 Immunosuppressives2120 (0.6)2244 (0.7)2604 (0.7)618 (1)61 (1)7647 (0.7)
 Antibiotics63,236 (18)59,525 (17)64,699 (18)12,447 (20)1336 (23)201,243 (18)
 Antimycotics5439 (2)3443 (1)2918 (0.8)307 (0.5)25 (0.4)12,132 (1)
 Antivirals4827 (1)4620 (1)4246 (1)436 (0.7)31 (0.5)14,160 (1)
Medical history, no. (%)
 Hypertension21,235 (6)75,650 (22)141,170 (39)46,093 (72)4885 (83)289,033 (25)
 Cardiovascular disease3168 (0.9)12,992 (4)37,358 (10)20,968 (33)2928 (50)77,414 (7)
  Myocardial infarction717 (0.2)4030 (1)10,238 (3)5812 (9)980 (17)21,777 (2)
  Congestive heart failure652 (0.2)2940 (0.9)13,334 (4)11,779 (19)2061 (35)30,766 (3)
  Peripheral vascular disease555 (0.2)2223 (0.6)6581 (2)3928 (6)600 (10)13,887 (1)
  Cerebrovascular disease1558 (0.4)5835 (2)16,139 (4)7762 (12)954 (16)32,248 (3)
 Diabetes10,336 (3)18,705 (5)27,590 (8)10,296 (16)1468 (25)68,395 (6)
 Cancer4880 (1)14,414 (4)27,576 (8)8168 (13)870 (15)55,908 (5)
 Chronic obstructive pulmonary disease7507 (2)10,461 (3)16,483 (5)5425 (9)632 (11)40,508 (4)
 Rheumatoid disease1719 (0.5)3284 (1)6989 (2)2858 (5)284 (5)15,134 (1)
 Dementia86 (0.02)880 (0.3)6051 (2)3530 (6)401 (7)10,948 (1)
 Peptic ulcer1223 (0.3)1965 (0.6)3063 (0.8)1389 (2)250 (4)7890 (0.7)
 Liver disease1120 (0.3)1550 (0.5)1679 (0.5)528 (0.8)62 (1)4939 (0.4)
 Hemiplegia/paraplegia1119 (0.3)742 (0.2)794 (0.2)235 (0.4)42 (0.7)2932 (0.3)
  • Recent or current use of medications considered any drug purchase at the time of or within the 6 mo proceeding the study start (index serum creatinine).