Study A Models | Annual Decline of eGFR≥3 ml/min per 1.73 m^{2} | |||||
---|---|---|---|---|---|---|

Unadjusted | Adjusted^{a} | |||||

Odds Ratio (95% CI) | P Value | C Statistic | Odds Ratio (95% CI) | P Value | C Statistic | |

Model 1: without FGF23^{a} | 4.41 (2.99 to 6.51) | <0.001 | 0.71 | 4.19 (2.67 to 6.60) | <0.001 | 0.74 |

Model 2: with FGF23^{a} | 4.27 (2.88 to 6.32) | <0.001 | 0.71 | 4.15 (2.63 to 6.53) | <0.001 | 0.74 |

The odds ratio estimate describes the association between height-adjusted total kidney volume and risk of rapid kidney function decline defined as ≥3 ml/min per 1.73 m

^{2}per year. In the entire cohort, the predicted probability of rapid kidney function decline was similar in models with and without FGF23. 95% CI, 95% confidence interval; FGF23, fibroblast growth factor 23.↵a With base model already including age, sex, body mass index, systolic BP, randomization group, calcium, phosphorus, eGFR, and urinary albumin excretion.