Table 6.

Association of height-adjusted total kidney volume with annual decline in eGFR≥3 ml/min per 1.73 m2 per year

Study A ModelsAnnual Decline of eGFR≥3 ml/min per 1.73 m2
UnadjustedAdjusteda
Odds Ratio (95% CI)P ValueC StatisticOdds Ratio (95% CI)P ValueC Statistic
Model 1: without FGF23a4.41 (2.99 to 6.51)<0.0010.714.19 (2.67 to 6.60)<0.0010.74
Model 2: with FGF23a4.27 (2.88 to 6.32)<0.0010.714.15 (2.63 to 6.53)<0.0010.74
  • The odds ratio estimate describes the association between height-adjusted total kidney volume and risk of rapid kidney function decline defined as ≥3 ml/min per 1.73 m2 per year. In the entire cohort, the predicted probability of rapid kidney function decline was similar in models with and without FGF23. 95% CI, 95% confidence interval; FGF23, fibroblast growth factor 23.

  • a With base model already including age, sex, body mass index, systolic BP, randomization group, calcium, phosphorus, eGFR, and urinary albumin excretion.