Table 5.

Main characteristics of 87 patients with pregnancy-associated hemolytic uremic syndrome with (n=49) or without complement gene variants (n=38)

CharacteristicsComplement Gene Variant Detected (n=49)No Complement Gene Variant Detected (n=38)P Value
At presentation
 Age, yr28±630±60.06
 Personal history of HUS4 (8%)3 (9%)1
 Onset in the postpartum39 (79%)28 (72%)0.49
 Need for dialysis35 (81%)21 (58%)0.02
 Neurologic involvement5 (12%)2 (6%)0.38
 Plasma exchange30 (79%)26 (77%)0.80
During follow-up, n=74
 Duration of follow-up, yr6.2±3.66.7±4.10.75
 Relapse13 (38%)5 (16%)0.04
 CKD9 (21%)6 (18%)0.81
 ESRD29 (64%)12 (36%)0.01
  • Data are mean ± SD for continuous variables, and N (%) for categorical variables. HUS, hemolytic uremic syndrome.