Variable | Placebo | Calcitriol | Calcifediol | Calcitriol versus Placebo | Calcifediol versus Placebo | Calcifediol versus Calcitriol |
---|---|---|---|---|---|---|

Pulse wave velocity, m/s | n=30 | n=28 | n=29 | |||

Unadjusted baseline, mean (SD) | 10.6 (3.6) | 12.2 (3.6) | 12.4 (4.4) | |||

Unadjusted 6 mo, mean (SD) | 11.7 (3.5) | 12.4 (3.5) | 11.3 (3.9) | |||

Unadjusted change (95% CI) at 6 mo^{a} | 1.1 (−0.1 to 2.2) | 0.2 (−0.9 to 1.4) | −1.1 (−2.2 to 0.1) | −0.8 (−2.8 to 1.1) | −2.1 (−4.1 to −0.2) | −1.3 (−3.2 to 0.7) |

P value^{a} | 0.55 | 0.03 | 0.26 | |||

Adjusted change (95% CI) at 6 mo^{b} | 0.7 (−0.3 to 1.7) | 0.4 (−0.6 to 1.4) | −0.8 (−1.8 to 0.2) | −0.3 (−2.0 to 1.5) | −1.5 (−3.2 to 0.3) | −1.2 (−2.9 to 0.5) |

P value^{b} | 0.93 | 0.11 | 0.23 | |||

Systolic BP, mmHg | n=35 | n=34 | n=33 | |||

Unadjusted baseline, mean (SD) | 138.8 (16.6) | 135.2 (13.0) | 140.2 (21.3) | |||

Unadjusted 6 mo, mean (SD) | 139.3 (10.8) | 135.7 (13.0) | 144.1 (23.6) | |||

Unadjusted change (95% CI) at 6 mo^{a} | 0.5 (−5.0 to 6.0) | 0.4 (−5.1 to 6.0) | 4.0 (−1.7 to 9.6) | −0.1 (−9.4 to 9.3) | 3.4 (−6.0 to 12.9) | 3.5 (−6.0 to 13.0) |

P value^{a} | 0.99 | 0.66 | 0.65 | |||

Adjusted change (95% CI) at 6 mo^{b} | 0.9 (−3.9 to 5.6) | −0.9 (−5.7 to 3.9) | 5.0 (0.1 to 9.9) | −1.8 (−9.9 to 6.3) | 4.1 (−4.0 to 12.3) | 5.9 (−2.4 to 14.2) |

P value^{b} | 0.60 | 0.45 | 0.21 | |||

Diastolic BP, mmHg | n=35 | n=34 | n=33 | |||

Unadjusted baseline, mean (SD) | 73.7 (11.8) | 70.0 (9.9) | 73.0 (13.1) | |||

Unadjusted 6 mo, mean (SD) | 75.1 (10.1) | 70.7 (9.1) | 75.0 (13.8) | |||

Unadjusted change (95% CI) at 6 mo^{a} | 1.4 (−1.6 to 4.4) | 0.7 (−2.3 to 3.8) | 2.0 (−1.1 to 5.2) | −0.7 (−5.8 to 4.5) | 0.6 (−4.6 to 5.8) | 1.3 (−4.0 to 6.5) |

P value^{a} | 0.83 | 0.96 | 0.83 | |||

Adjusted change (95% CI) at 6 mo^{b} | 1.9 (−0.8 to 4.6) | −0.0 (−2.8 to 2.8) | 2.3 (−0.5 to 5.1) | −1.9 (−6.6 to 2.8) | 0.4 (−4.3 to 5.1) | 2.3 (−2.4 to 7.1) |

P value^{b} | 0.59 | 0.98 | 0.48 | |||

Urine ACR, ln(mg/g) | n=35 | n=31 | n=32 | |||

Unadjusted baseline, mean (SD) | 5.3 (2.1) | 5.1 (1.6) | 5.2 (2.0) | |||

Unadjusted 6 mo, mean (SD) | 5.4 (2.1) | 5.0 (1.8) | 5.2 (2.1) | |||

Unadjusted change (95% CI) at 6 mo^{a} | 0.1 (−0.1 to 0.3) | −0.1 (−0.3 to 0.1) | 0.0 (−0.2 to 0.2) | −0.2 (−0.5 to 0.2) | −0.1 (−0.5 to 0.3) | 0.8 (−0.3 to 0.5) |

P value^{a} | 0.54 | 0.85 | 0.87 | |||

Adjusted change (95% CI) at 6 mo^{b} | 0.1 (−0.1 to 0.3) | −0.1 (−0.3 to 0.1) | 0.0 (−0.2 to 0.2) | −0.2 (−0.5 to 0.2) | −0.1 (−0.5 to 0.3) | 0.8 (−0.3 to 0.5) |

P value^{b} | 0.54 | 0.85 | 0.87 | |||

Calcium, mg/dl | n=35 | n=34 | n=33 | |||

Unadjusted baseline, mean (SD) | 9.3 (0.4) | 9.3 (0.5) | 9.2 (0.5) | |||

Unadjusted 6 mo, mean (SD) | 9.0 (1.2) | 9.4 (0.5) | 9.3 (0.5) | |||

Unadjusted change (95% CI) at 6 mo^{a} | −0.3 (−0.5 to −0.0) | 0.1 (−0.2 to 0.4) | 0.1 (−0.2 to 0.4) | 0.4 (−0.1 to 0.8) | 0.4 (−0.1 to 0.8) | −0.0 (−0.4 to 0.4) |

P value^{a} | 0.10 | 0.11 | >0.99 | |||

Adjusted change (95% CI) at 6 mo^{b} | −0.3 (−0.5 to −0.0) | 0.1 (−0.1 to 0.4) | 0.1 (−0.2 to 0.3) | 0.4 (−0.0 to 0.8) | 0.4 (−0.1 to 0.8) | −0.0 (−0.5 to 0.4) |

P value^{b} | 0.09 | 0.12 | 0.99 | |||

Phosphate, mg/dl | n=35 | n=34 | n=33 | |||

Unadjusted baseline, mean (SD) | 3.5 (0.7) | 3.4 (0.6) | 3.5 (0.7) | |||

Unadjusted 6 mo, mean (SD) | 3.6 (0.8) | 3.6 (0.8) | 3.6 (0.8) | |||

Unadjusted change (95% CI) at 6 mo^{a} | 0.2 (−0.0 to 0.4) | 0.2 (−0.0 to 0.4) | 0.2 (−0.0 to 0.4) | 0.0 (−0.3 to 0.3) | −0.0 (−0.4 to 0.3) | −0.0 (−0.4 to 0.3) |

P value^{a} | 0.99 | 0.99 | 0.97 | |||

Adjusted change (95% CI) at 6 mo^{b} | 0.2 (−0.0 to 0.4) | 0.2 (−0.0 to 0.4) | 0.2 (−0.0 to 0.4) | 0.0 (−0.3 to 0.3) | −0.0 (−0.3 to 0.3) | −0.0 (−0.4 to 0.3) |

P value^{b} | 0.99 | 0.99 | 0.97 | |||

PTH, ln(pg/ml) | n=35 | n=33 | n=33 | |||

Unadjusted baseline, mean (SD) | 4.9 (0.7) | 4.6 (0.7) | 4.6 (0.7) | |||

Unadjusted 6 mo, mean (SD) | 5.0 (0.8) | 4.4 (0.8) | 4.1 (0.9) | |||

Unadjusted change (95% CI) at 6 mo^{a} | 0.1 (−0.0 to 0.3) | −0.3 (−0.4 to −0.1) | −0.5 (−0.6 to −0.3) | −0.4 (−0.7 to −0.1) | −0.6 (−0.9 to −0.3) | −0.2 (−0.5 to 0.1) |

P value^{a} | <0.01 | <0.001 | 0.24 | |||

Adjusted change (95% CI) at 6 mo^{b} | 0.2 (−0.0 to 0.3) | −0.2 (−0.4 to −0.1) | −0.5 (−0.6 to −0.3) | −0.4 (−0.7 to −0.1) | −0.6 (−0.9 to −0.3) | −0.2 (−0.5 to 0.1) |

P value^{b} | <0.01 | <0.001 | 0.22 | |||

FGF-23, ln(pg/ml) | n=33 | n=32 | n=33 | |||

Unadjusted baseline, mean (SD) | 5.0 (0.7) | 4.7 (0.9) | 4.7 (0.9) | |||

Unadjusted 6 mo, mean (SD) | 5.0 (0.9) | 4.9 (1.0) | 4.9 (0.9) | |||

Unadjusted change (95% CI) at 6 mo^{a} | 0.1 (−0.1 to 0.3) | 0.2 (0.0 to 0.3) | 0.2 (0.1 to 0.4) | 0.1 (−0.2 to 0.4) | 0.1 (−0.1 to 0.4) | 0.1 (−0.2 to 0.3) |

P value^{a} | 0.70 | 0.41 | 0.89 | |||

Adjusted change (95% CI) at 6 mo^{b} | 0.1 (−0.1 to 0.3) | 0.2 (0.0 to 0.3) | 0.2 (0.1 to 0.4) | 0.1 (−0.2 to 0.4) | 0.1 (−0.1 to 0.4) | 0.1 (−0.2 to 0.3) |

P value^{b} | 0.71 | 0.43 | 0.89 | |||

CRP, ln(mg/L) | n=34 | n=32 | n=33 | |||

Unadjusted baseline, mean (SD) | 0.3 (1.0) | 0.4 (1.3) | 0.6 (1.2) | |||

Unadjusted 6 mo, mean (SD) | 0.2 (1.0) | 0.5 (1.1) | 0.6 (1.1) | |||

Unadjusted change (95% CI) at 6 mo^{a} | −0.1 (−0.4 to 0.2) | 0.1 (−0.2 to 0.3) | 0.0 (−0.2 to 0.3) | 0.1 (−0.3 to 0.6) | 0.1 (−0.4 to 0.6) | −0.0 (−0.5 to 0.4) |

P value^{a} | 0.75 | 0.83 | 0.99 | |||

Adjusted change (95% CI) at 6 mo^{b} | −0.1 (−0.4 to 0.1) | 0.1 (−0.2 to 0.3) | 0.1 (−0.2 to 0.3) | 0.2 (−0.2 to 0.6) | 0.2 (−0.2 to 0.6) | 0.0 (−0.4 to 0.4) |

P value^{b} | 0.54 | 0.51 | >0.99 | |||

25(OH)D, ng/ml | n=33 | n=32 | n=32 | |||

Unadjusted baseline, mean (SD) | 29.1 (11.4) | 26.7 (10.8) | 25.8 (9.6) | |||

Unadjusted 6 mo, mean (SD) | 26.2 (11.6) | 23.8 (8.9) | 94.1 (51.9) | |||

Unadjusted change (95% CI) at 6 mo^{a} | −2.9 (−13.0 to 7.2) | −2.9 (−13.2 to 7.3) | 68.3 (58.1 to 78.6) | −0.0 (−17.3 to 17.2) | 71.2 (54.0 to 88.5) | 71.3 (53.9 to 88.7) |

P value^{a} | >0.99 | <0.001 | <0.001 | |||

Adjusted change (95% CI) at 6 mo^{b} | −2.8 (−13.0 to 7.4) | −2.9 (−13.2 to 7.4) | 68.3 (58.0 to 78.6) | −0.1 (−17.5 to 17.3) | 71.1 (53.6 to 88.6) | 71.2 (53.7 to 88.7) |

P value^{b} | >0.99 | <0.001 | <0.001 | |||

1,25(OH)_{2}D, pg/ml | n=33 | n=31 | n=32 | |||

Unadjusted baseline, mean (SD) | 20.3 (7.4) | 21.7 (10.2) | 23.9 (10.9) | |||

Unadjusted 6 mo, mean (SD) | 21.7 (7.6) | 27.2 (10.9) | 27.5 (14.3) | |||

Unadjusted change (95% CI) at 6 mo^{a} | 1.4 (−2.6 to 5.4) | 5.5 (1.4 to 9.7) | 3.5 (−0.5 to 7.6) | 4.2 (−2.7 to 11.0) | 2.2 (−4.7 to 9.0) | −2.0 (−8.9 to 5.0) |

P value^{a} | 0.33 | 0.73 | 0.78 | |||

Adjusted change (95% CI) at 6 mo^{b} | 0.5 (−3.1 to 4.1) | 5.4 (1.7 to 9.1) | 4.6 (0.9 to 8.3) | 4.9 (−1.3 to 11.1) | 4.1 (−2.1 to 10.4) | −0.8 (−7.1 to 5.5) |

P value^{b} | 0.15 | 0.25 | 0.95 |

SI conversion factors: to convert urine ACR to mg/mmol, multiply by 0.113; to convert calcium to mmol/L, multiply by 0.25; to convert phosphate to mmol/L, multiply by 0.323; to convert PTH to pmol/L, multiply by 0.106; to convert 25(OH)D to nmol/L, multiply by 2.496; to convert 1,25(OH)

_{2}D to pmol/L, multiply by 2.6. 95% CI, 95% confidence interval; ACR, albumin-to-creatinine ratio; PTH, parathyroid hormone; FGF-23, fibroblast growth factor 23; CRP, C-reactive protein; 25(OH)D, 25-hydroxyvitamin D; 1,25(OH)_{2}D, 1,25-dihydroxyvitamin D.↵a

*P*values and 95% CIs adjusted for multiple comparisons using the Tukey–Kramer method.↵b Analysis of covariance results: adjusted mean, 95% CI, and

*P*value for treatment effects with the respective baseline value as covariate.