Table 1.

Characteristics of 87 patients with pregnancy-associated hemolytic uremic syndrome

CharacteristicsNumber (%)/Mean±SD
Number of patients87
Age at HUS onset, yr29±6.0
Number of previous pregnancies0.7±1.2
Rank of pregnancy HUS was diagnosed in (n=83)
 First48 (58)
 Second23 (28)
 Third5 (6)
 Fourth or subsequent7 (8)
Preeclampsia during previous pregnancies (n=53)5 (9)
Fetal loss during previous pregnancies (n=49)10 (20)
Familial history of atypical HUS14 (16)
Personal history of atypical HUS7 (8)
Timing of HUSa
 Postpartum63 (76)
 During pregnancy20 (24)
Features at hemolytic and uremic syndrome onset
 Serum creatinine, mg/dl6.1±5.2
 Dialysis56 (71)
 Platelet count ×103, per μl97±99
 Hemoglobin, g/dl (n=66)7.8±1.9
 Lactate dehydrogenase, U/L (n=56)2225±1617
 Neurologic involvement7 (9)
 Other extrarenal manifestationsb4 (6)
Treatment
 Number of patients who underwent plasma exchange (n=72)56 (78)
 Number of plasma exchange sessions performed per patient (n=41)13±10
 Number of patients who received plasma infusion (n=51)21 (41)
 Number of patients who received eculizumab4 (5)
 Steroids (n=60)16 (27)
 Otherc3 (5)
  • The numbers of patients for whom data are available are reported in brackets. HUS, hemolytic uremic syndrome.

  • a Timing of HUS is unknown for four patients.

  • b Pulmonary edema (n=2), pulmonary embolism (n=1).

  • c Intravenous Igs (n=2), rituximab (n=1).