Variable^{a} | Coefficient Interpretation | Coefficient Estimate | Coefficient SEM | P Value |
---|---|---|---|---|

APOL1 high risk | Difference in average baseline eGFR (milliliters per minute per 1.73 m^{2}) among African ancestry participants with APOL1 high-risk alleles compare with whites | −3.36 | 1.13 | 0.003 |

APOL1 low risk | Difference in average baseline eGFR (milliliters per minute per 1.73 m^{2}) among African ancestry participants with APOL1 low-risk alleles compare with whites | −3.87 | 0.63 | <0.001 |

Years | Average eGFR slope (milliliters per minute per 1.73 m^{2} per year) among whites | −0.50 | 0.06 | <0.001 |

Years × APOL1 high risk | Difference in average eGFR slope (milliliters per minute per 1.73 m^{2} per year) among African ancestry participants with APOL1 high-risk alleles and whites | −0.94 | 0.21 | <0.001 |

Years × APOL1 low risk | Difference in average eGFR slope (milliliters per minute per 1.73 m^{2} per year) among African ancestry participants with APOL1 low-risk alleles and whites | −0.38 | 0.11 | <0.001 |

Results are from a generalized estimating equation model fit for the Chronic Renal Insufficiency Cohort Study example in model 1 under exchangeable correlation structure.

↵a Model 1:

*APOL1*is the exposure variable of the genotype in conjunction with race with three categories (0, white; 1,*APOL1*low risk; and 2,*APOL1*high risk), with whites as the reference group. The reported coefficient SEMs are the robust estimates combining empirical data correlation and the assumed working correlation structure.