Table 1.

Adjusted risk of graft failure at 5 years by characteristic for each transplant donor type for transplants from 1998 to 2012

CharacteristicaLUR DonorLR DonorDeceased Donor
(n=32,349)(n=56,660)(n=143,696)
N (%)HR (95% CI)N (%)HR (95% CI)NHR (95% CI)
Recipient age, yr
 <13316 (1)1.12 (0.77 to 1.63)2594 (5)1.01 (0.88 to 1.16)2791 (2)1.40 (1.28 to 1.54)
 13–17304 (1)2.49 (1.93 to 3.21)2123 (4)2.02 (1.80 to 2.26)3454 (2)2.05 (1.90 to 2.20)
 18–292577 (8)1.72 (1.53 to 1.94)9104 (16)1.59 (1.48 to 1.72)9461 (7)1.48 (1.41 to 1.55)
 30–395384 (17)1.11 (1.00 to 1.23)9818 (17)1.10 (1.02 to 1.19)18,601 (13)1.10 (1.06 to 1.14)
 40–498709 (27)1.00 (Ref)11,019 (19)1.00 (Ref)29,918 (21)1.00 (Ref)
 50–599031 (28)1.08 (0.99 to 1.18)11,853 (21)1.10 (1.02 to 1.18)39,454 (28)1.12 (1.09 to 1.16)
 60+6028 (19)1.57 (1.43 to 1.73)10,149 (18)1.39 (1.29 to 1.50)40,017 (28)1.46 (1.41 to 1.51)
Donor age, yr
 <1818,812 (13)0.78 (0.75 to 0.81)
 18–294141 (13)0.88 (0.80 to 0.98)12,609 (22)0.89 (0.84 to 0.95)33,500 (23)0.76 (0.73 to 0.79)
 30–397845 (24)0.93 (0.85 to 1.01)17,090 (30)0.92 (0.87 to 0.98)20,835 (15)0.84 (0.81 to 0.87)
 40–4910,448 (32)1.00 (Ref)16,472 (29)1.00 (Ref)30,744 (21)1.00 (Ref)
 50–597698 (24)1.14 (1.05 to 1.24)8691 (15)1.07 (1.00 to 1.14)27,289 (19)1.20 (1.17 to 1.24)
 60+2217 (7)1.38 (1.23 to 1.56)1798 (3)1.42 (1.26 to 1.59)12,516 (9)1.52 (1.46 to 1.58)
Donor-recipient sex
 Female-female5828 (18)1.01 (0.92 to 1.11)14,549 (26)1.07 (1.00 to 1.14)23,567 (16)0.93 (0.89 to 0.96)
 Male-female5922 (18)1.07 (0.96 to 1.19)9371 (17)1.03 (0.95 to 1.12)33,227 (23)0.94 (0.91 to 0.98)
 Female-male14,765 (46)1.00 (Ref)17,773 (31)1.00 (Ref)34,420 (24)1.00 (Ref)
 Male-male5834 (18)0.87 (0.79 to 0.95)14,967 (26)0.89 (0.83 to 0.95)52,482 (37)0.95 (0.92 to 0.98)
HLA ABDR mismatch
 0 MM162 (1)0.69 (0.42 to 1.12)7869 (14)0.62 (0.57 to 0.67)15,171 (11)0.83 (0.80 to 0.86)
 1–2 MM, 0 DR MM847 (3)0.73 (0.59 to 0.91)8512 (15)0.93 (0.88 to 1.00)5796 (4)0.87 (0.82 to 0.92)
 1–2 MM, 1–2 DR MM993 (3)0.85 (0.70 to 1.02)10,308 (18)0.95 (0.89 to 1.01)6103 (4)0.95 (0.90 to 1.00)
 3–4 MM, 0 DR MM1350 (4)0.91 (0.77 to 1.06)532 (1)0.99 (0.79 to 1.24)10,557 (7)0.91 (0.87 to 0.95)
 3–4 MM, 1–2 DR MM12,149 (38)1.00 (Ref)23,413 (41)1.00 (Ref)44,692 (31)1.00 (Ref)
 5,6, missing MM16,848 (52)1.06 (1.00 to 1.13)6026 (11)1.06 (0.99 to 1.14)61,377 (43)1.08 (1.06 to 1.11)
Recipient BMI (kg/m2)
 Not obese (<30)20,508 (63)1.00 (Ref)36,876 (65)1.00 (Ref)88,565 (62)1.00 (Ref)
 Obese (>30)8637 (27)1.18 (1.09 to 1.28)12,112 (21)1.15 (1.08 to 1.22)37,269 (26)1.08 (1.05 to 1.11)
 Missing3204 (10)1.03 (0.89 to 1.19)7672 (14)1.17 (1.07 to 1.28)17,862 (12)0.93 (0.86 to 1.01)
Donor BMI
 Not obese (<30)22,355 (69)1.00 (Ref)35,679 (63)1.00 (Ref)109,771 (76)1.00 (Ref)
 Obese (>30)6307 (20)1.11 (1.02 to 1.20)10,948 (19)1.05 (0.98 to 1.11)33,268 (23)1.07 (1.04 to 1.10)
 Missing3687 (11)0.94 (0.78 to 1.13)10,033 (18)1.08 (0.95 to 1.22)657 (1)1.05 (0.90 to 1.22)
Donor-recipient weight ratio
 <0.756388 (20)1.12 (1.01 to 1.25)6526 (12)1.09 (1.00 to 1.19)30,333 (21)1.12 (1.08 to 1.16)
 0.75–0.906239 (19)1.06 (0.96 to 1.16)8568 (15)0.98 (0.91 to 1.06)23,538 (16)1.04 (1.00 to 1.08)
 0.90–1.158113 (25)1.00 (Ref)14,951 (26)1.00 (Ref)35,606 (25)1.00 (Ref)
 >1.157606 (24)1.09 (0.99 to 1.21)16,193 (29)0.97 (0.90 to 1.03)43,162 (30)1.00 (0.96 to 1.03)
 Missing4003 (12)1.16 (0.99 to 1.36)10,422 (18)1.06 (0.95 to 1.18)11,057 (8)1.26 (1.18 to 1.35)
Donor-recipient height ratio
 <0.948480 (26)1.13 (1.01 to 1.27)8978 (16)1.08 (0.99 to 1.18)30,240 (21)1.05 (1.02 to 1.09)
 0.94–1.006851 (21)1.02 (0.92 to 1.13)11,053 (20)1.00 (0.93 to 1.08)29,183 (20)1.00 (0.97 to 1.03)
 1.00–1.066180 (19)1.00 (Ref)13,042 (23)1.00 (Ref)34,057 (24)1.00 (Ref)
 >1.065757 (18)0.96 (0.86 to 1.07)10,748 (19)0.98 (0.91 to 1.07)38,460 (27)0.94 (0.91 to 0.98)
 Missing5081 (16)1.04 (0.87 to 1.25)12,839 (23)0.91 (0.81 to 1.02)11,756 (8)1.11 (1.04 to 1.19)
Recipient race/ethnicity
 White23,515 (73)1.00 (Ref)36,590 (65)1.00 (Ref)69,709 (49)1.00 (Ref)
 Black3930 (12)1.22 (1.09 to 1.38)8863 (16)1.28 (1.06 to 1.53)43,656 (30)1.15 (1.12 to 1.18)
 Hispanic3166 (10)0.96 (0.83 to 1.10)8391 (15)0.85 (0.73 to 0.98)20,065 (14)0.79 (0.76 to 0.82)
 Other1738 (5)0.82 (0.71 to 0.96)2816 (5)0.67 (0.59 to 0.76)10,266 (7)0.75 (0.71 to 0.78)
Donor race/ethnicity
 Not black or Hispanic26,676 (83)1.00 (Ref)39,484 (70)1.00 (Ref)105,874 (74)1.00 (Ref)
 Black2703 (8)1.12 (0.97 to 1.28)8708 (15)1.10 (0.91 to 1.32)18,700 (13)1.24 (1.20 to 1.27)
 Hispanic2970 (9)0.84 (0.73 to 0.97)8468 (15)0.91 (0.79 to 1.05)19,122 (13)1.02 (0.98 to 1.05)
Donor history of cigarette use
 No15,537 (48)1.00 (Ref)20,611 (36)1.00 (Ref)6108 (4)1.00 (Ref)
 Yes4917 (15)1.09 (0.99 to 1.20)6744 (12)1.08 (0.99 to 1.17)43,128 (30)1.09 (1.04 to 1.15)
 Missing11,895 (37)1.15 (1.05 to 1.26)29,305 (52)1.18 (1.10 to 1.27)94,460 (66)1.04 (0.99 to 1.10)
ABO compatibility
 Not incompatible31,895 (99)1.00 (Ref)56,086 (99)1.00 (Ref)143,374 (100)1.00 (Ref)
 Incompatible454 (1)1.51 (1.22 to 1.87)574 (1)1.36 (1.11 to 1.66)322 (0)1.16 (0.94 to 1.43)
PRA
 0–926,473 (82)1.00 (Ref)47,022 (83)1.00 (Ref)111,404 (78)1.00 (Ref)
 10–794079 (13)1.09 (0.99 to 1.20)6408 (11)1.11 (1.03 to 1.19)21,784 (15)1.11 (1.07 to 1.14)
 80+730 (2)1.35 (1.12 to 1.63)1321 (2)1.45 (1.27 to 1.65)8278 (6)1.27 (1.21 to 1.34)
 Missing1067 (3)0.87 (0.71 to 1.06)1909 (3)0.93 (0.81 to 1.07)2230 (2)1.22 (1.10 to 1.34)
Recipient diagnosis
 Not diabetes25,264 (78)1.00 (Ref)45,337 (80)1.00 (Ref)110,370 (77)1.00 (Ref)
 Diabetes7085 (22)1.32 (1.23 to 1.41)11,323 (20)1.30 (1.23 to 1.37)33,326 (23)1.27 (1.24 to 1.30)
Previous transplant
 No28,584 (88)1.00 (Ref)51,219 (90)1.00 (Ref)125,104 (87)1.00 (Ref)
 Yes3765 (12)1.41 (1.29 to 1.55)5441 (10)1.16 (1.08 to 1.25)18,592 (13)1.19 (1.15 to 1.23)
Time on dialysis
 Preemptive transplant10,712 (33)0.71 (0.65 to 0.77)18,103 (32)0.64 (0.60 to 0.68)16,749 (12)0.86 (0.82 to 0.90)
 0–1 yr8948 (28)0.82 (0.75 to 0.89)17,441 (31)0.85 (0.80 to 0.91)15,984 (11)0.98 (0.94 to 1.02)
 1–2 yr5864 (18)1.00 (Ref)10,684 (19)1.00 (Ref)21,618 (15)1.00 (Ref)
 2–3 yr2905 (9)0.97 (0.86 to 1.08)4681 (8)0.99 (0.91 to 1.08)22,147 (15)1.03 (0.99 to 1.07)
 3+ yr3920 (12)1.07 (0.96 to 1.18)5751 (10)1.05 (0.97 to 1.13)67,198 (47)1.12 (1.08 to 1.15)
Recipient hepatitis C serology
 Negative or missing31,419 (97)1.00 (Ref)55,147 (97)1.00 (Ref)134,430 (94)1.00 (Ref)
 Positive930 (3)1.51 (1.31 to 1.74)1513 (3)1.46 (1.31 to 1.63)9266 (6)1.45 (1.40 to 1.51)
Recipient insurance
 Public primary payer11,346 (35)1.00 (Ref)22,824 (40)1.00 (Ref)96,508 (67)1.00 (Ref)
 Private primary payer20,184 (62)0.77 (0.72 to 0.82)31,892 (56)0.80 (0.77 to 0.84)42,478 (30)0.82 (0.80 to 0.84)
 Other/missing819 (3)0.83 (0.69 to 1.01)1944 (3)0.92 (0.81 to 1.03)4710 (3)0.94 (0.89 to 1.00)
Transplant year
 1998–20027013 (22)1.00 (Ref)19,810 (35)1.00 (Ref)40,977 (29)1.00 (Ref)
 2003–200711,609 (36)0.83 (0.76 to 0.90)20,553 (36)0.93 (0.87 to 0.99)49,191 (34)0.82 (0.80 to 0.84)
 2008–201213,727 (42)0.63 (0.55 to 0.71)16,297 (29)0.78 (0.71 to 0.85)53,528 (37)0.62 (0.60 to 0.64)
  • LUR, living unrelated; LR, living related; HR, hazard ratio; 95% CI, 95% confidence interval; Ref, reference group; —, not included in study; MM, mismatch; BMI, body mass index; PRA, panel reactive antibody;

  • a Adjusted for transplant year, ESRD cause, PRA at transplant, previous transplant, years of ESRD, hepatitis C serology, insurance, and recipient and donor race and ethnicity, donor history of cigarette use, and the following donor-recipient combinations: age, sex, obesity status, weight ratio, height ratio, HLA mismatch, and ABO compatibility.