Table 2.

Association of measures of adiposity with kidney function decline

VariableNΔeGFR>30%Unadjusted
OR (95% CI)Model 1a
OR (95% CI)Model 2b
OR (95% CI)
Subcutaneous fat
 Continuous (per SD=121)24894341.2 (1.0 to 1.3)1.3 (1.1 to 1.4)1.18 (1.04 to 1.33)
 Quartiles
  <1966211031.0 (ref)1.0 (ref)1.0 (ref)
  196–267619970.9 (0.7 to 1.3)1.0 (0.7 to 1.3)0.9 (0.7 to 1.3)
  268–3576331081.0 (0.8 to 1.4)1.1 (0.8 to 1.6)1.0 (0.8 to 1.4)
  >3576161261.3 (1.0 to 1.7)1.6 (1.1 to 2.2)1.4 (1.0 to 1.9)
Visceral fat
 Continuous (per SD=67)24894341.3 (1.2 to 1.4)1.3 (1.9 to 1.5)1.2 (1.0 to 1.3)
 Quartiles
  <94618881.0 (ref)1.0 (ref)1.0 (ref)
  94–132626891.0 (0.7 to 1.3)1.0 (0.7 to 1.4)0.91 (0.7 to 1.3)
  133–1816251151.4 (1.0 to 1.9)1.4 (1.0 to 1.9)1.2 (0.9 to 1.6)
  >1816201421.8 (1.4 to 2.4)1.9 (1.4 to 2.5)1.38 (1.0 to 1.9)
R thigh intermuscular fat area, cm2
 Continuous (per SD=6.8)24814301.2 (1.1 to 1.3)1.2 (1.1 to 1.3)1.1 (1.0 to 1.2)
 Quartiles
  <6.15631831.0 (ref)1.0 (ref)1.0 (ref)
  6.15–9.016411041.3 (1.0 to 1.8)1.3 (1.0 to 1.8)1.3 (1.0 to 1.8)
  9.02–13.126201131.5 (1.1 to 2.1)1.5 (1.1 to 2.1)1.4 (1.0 to 1.9)
  >13.125891301.9 (1.4 to 2.6)1.9 (1.4 to 2.6)1.5 (1.1 to 2.1)
Waist circumference
Continuous (per SD=12.5)24884341.3 (1.2 to 1.5)1.3 (1.2 to 1.5)1.2 (1.1 to 1.4)
 Quartiles
  <91.7616811.0 (ref)1.0 (ref)1.0 (ref)
  91.7–99.2645981.2 (0.9 to 1.6)1.2 (0.8 to 1.6)1.2 (0.8 to 1.6)
  99.3–107.16311181.6 (1.2 to 2.1)1.5 (1.1 to 2.1)1.4 (1.0 to 2.0)
  >107.15961372.0 (1.5 to 2.7)1.9 (1.4 to 2.6)1.6 (1.1 to 2.2)
BMI
 Continuous (per SD=4.6)24894341.3 (1.2 to 1.4)1.3 (1.2 to 1.4)1.2 (1.0 to 1.3)
 Quartiles
  <24.1615851.0 (ref)1.0 (ref)1.0 (ref)
  24.1–26.8641971.1 (0.8 to 1.5)1.1 (0.8 to 1.5)1.1 (0.8 to 1.5)
  26.9–30.06381191.5 (1.1 to 2.0)1.5 (1.1 to 2.0)1.3 (0.9 to 1.8)
  >30.15951331.8 (1.3 to 2.4)1.8 (1.3 to 2.5)1.5 (1.1 to 2.1)
  • OR, odds ratio; 95% CI, 95% confidence interval; ref, reference; R, right; BMI, body mass index.

  • a Adjusted for age, sex, race, and site.

  • b Further adjusted for diabetes mellitus, systolic blood pressure, hypertension meds, albumin-to-creatinine ratio, smoking, LDL cholesterol, HDL cholesterol, oral estrogen, prevalent coronary heart disease, prevalent heart failure, and C-reactive protein. Kidney function decline was defined as eGFR-cystatin C decline >30%.