Table 5.

Association of measures of adiposity with incident CKD

VariableNInc CKDRate (%/yr)Unadjusted
IRR (95% CI)Model 1a
IRR (95% CI)Model 2b
IRR (95% CI)
Subcutaneous fat
 Continuous (per SD=121)22953922.81.2 (1.1 to 1. 3)1.1 (1.0 to 1.3)1.1 (1.0 to 1.2)
 Quartiles
  <196577852.41.0 (ref)1.0 (ref)1.0 (ref)
  196–267571832.41.0 (0.7 to 1.3)0.9 (0.7 to 1.2)0.9 (0.7 to 1.2)
  268–3575931072.91.2 (0.9 to 1.6)1.2 (0.9 to 1.6)1.1 (0.8 to 1.4)
  >3575541173.51.5 (1.1 to 1.9)1.3 (1.0 to 1.8)1.2 (0.9 to 1.6)
Visceral fat
 Continuous (per SD=67)22953922.81. 4 (1.3 to 1.5)1.2 (1.1 to 1.4)1.2 (1.1 to 1.3)
 Quartiles
  <94584651.81.0 (ref)1.0 (ref)1.0 (ref)
  94–132591892.31.3 (1.0 to 1.8)1.2 (0.8 to 1.5)1.1 (0.8 to 1.4)
  133–1815721032.91.6 (1.2 to 2.2)1.2 (0.9 to 1.7)1.2 (0.9 to 1.5)
  >1815481354.22.3 (1.7 to 3.1)1.6 (1.1 to 2.2)1.5 (1.1 to 2.0)
R thigh intermuscular fat area, cm2
 Continuous (per SD=6.8)22883882.81.2 (1.1 to 1.3)1.1 (1.1 to 1.3)1.1 (1.0 to 1.2)
 Quartiles
  <6.15599691.81.0 (ref)1.0 (ref)1.0 (ref)
  6.15–9.01605952.51.4 (1.0 to 1.9)1.2 (0.9 to 1.6)1.2 (0.9 to 1.6)
  9.02–13.125671173.41.9 (1.4 to 2.5)1.5 (1.1 to 1.9)1.4 (1.1 to 1.9)
  >13.125171073.62.0 (1.5 to 2.7)1.5 (1.1 to 2.0)1.4 (1.1 to 1.9)
Waist circumference
 Continuous (per SD=12.5)22943922.81.3 (1.2 to 1.4)1.2 (1.1 to 1.3)1.2 (1.1 to 1.3)
 Quartiles
  <91.7582691.91.0 (ref)1.0 (ref)1.0 (ref)
  91.7–99.2597892.41.3 (0.9 to 1.7)1.2 (0.9 to 1.7)1.2 (0.9 to 1.6)
  99.3–107.15861103.11.6 (1.2 to 2.2)1.3 (1.0 to 1.7)1.2 (0.9 to 1.7)
  >107.15291244.02.1 (1.6 to 2.8)1.6 (1.2 to 2.1)1.4 (1.1 to 1.9)
BMI
 Continuous (per SD=4.6)22953922.81.2 (1.2 to 1.4)1.2 (1.1 to 1.3)1.2 (1.0 to 1.3)
 Quartiles
  <24.1575712.01.0 (ref)1.0 (ref)1.0 (ref)
  24.1–26.8607912.41.2 (0.9 to 1.6)1.1 (0.8 to 1.5)1.1 (0.8 to 1.4)
  26.9–30.05801022.81.4 (1.1 to 1.9)1.1 (0.9 to 1.5)1.1 (0.8 to 1.5)
  >30.15331284.12.0 (1.5 to 2.7)1.6 (1.2 to 2.1)1.4 (1.1 to 1.9)
  • Incident CKD was defined as a follow-up eGFRcysC≤60 ml/min per 1.73 m2 in individuals with baseline GFR>60 ml/min per 1.73 m2. Inc, incident; IRR, incident rate ratio; 95% CI, 95% confidence interval; ref, reference; R, right; BMI, body mass index.

  • a Adjusted for age, sex, race, site, and baseline eGFR.

  • b Further adjusted for diabetes mellitus, systolic blood pressure, hypertension meds, albumin-to-creatinine ratio, smoking, LDL cholesterol, HDL cholesterol, oral estrogen, prevalent coronary heart disease, and prevalent heart failure.