Table 4.

Association of measures of adiposity with kidney function decline using eGFRcr

VariableNΔeGFR-Cr>30%Unadjusted
OR (95% CI)Model 1a
OR (95% CI)Model 2b
OR (95% CI)
Subcutaneous fat
 Continuous (per SD=121)12193391.2 (1.1 to 1.4)1.2 (1.0 to 1.4)1.1 (0.9 to 1.3)
 Quartiles
  <196295721.0 (ref)1.0 (ref)1.0 (ref)
  196–267301711.0 (0.7 to 1.4)1.0 (0.7 to 14)0.9 (0.6 to 1.3)
  268–357322921.2 (0.9 to 1.8)1.2 (0.8 to 1.7)1.0 (0.7 to 1.5)
  >3573011041.6 (1. 1 to 2.3)1.5 (1.0 to 2. 2)1.2 (0.8 to 1.9)
Visceral fat
 Continuous (per SD=67)12193391.2 (1.0 to 1.3)1.2 (1.2 to 1.4)1.1 (0.9 to 1.3)
 Quartiles
  <94296691.0 (ref)1.0 (ref)1.0 (ref)
  94–132312821.2 (0.9 to 1.8)1.3 (0.9 to 1.9)1.2 (0.8 to 1.8)
  133–181315961.6 (1.1 to 2.2)1.3 (1.2 to 2.4)1.4 (1.0 to 2.1)
  >181296931.7 (1.2 to 2.5)1.8 (1.2 to 2.7)1.4 (0.9 to 2.1)
R thigh intermuscular fat area, cm2
 Continuous (per SD=6.8)12153371.2 (1.0 to 1.4)1.1 (1.0 to 1.3)1.0 (0.9 to 1.2)
 Quartiles
  <6.15329841.0 (ref)1.0 (ref)1.0 (ref)
  6.15–9.01332810.9 (0.7 to 1.3)0.9 (0.6 to 1.3)0.8 (0.6 to 1.2)
  9.02–13.12297961.4 (1.0 to 2.0)1.3 (0.3 to 1.9)1.1 (0.8 to 1.6)
  >13.12257761.2 (0.8 to 1.7)1.1 (0.7 to 1.6)0.8 (0.6 to 1.3)
Waist circumference
 Continuous (per SD=12.5)12193391.2 (1.1 to 1.4)1.2 (1.1 to 1.4)1.1 (1.0 to 1.3)
 Quartiles
  <91.7306771.0 (ref)1.0 (ref)1.0 (ref)
  91.7–99.2328770.9 (0.7 to 1.4)1.0 (0.7 to 1.4)0.9 (0.6 to 1.4)
  99.3–107.1311931.3 (0.9 to 1.8)1.3 (0.9 to 1.9)1.2 (0.8 to 1.8)
  >107.1274921.5 (1.2 to 2. 2)1.5 (1.0 to 2.2)1.2 (0.8 to 1.8)
BMI
 Continuous (per SD=4.6)12193391.2 (1.1 to 1.4)1.2 (1.1 to 1.4)1.1 (0.9 to 1.3)
 Quartiles
  <24.1292681.0 (ref)1.0 (ref)1.0 (ref)
  24.1–26.8329781.1 (0.7 to 1.6)1.2 (0.8 to 1.7)1.1 (0.7 to 1.6)
  26.9–30.0324971.5 (1.0 to 2.2)1.6 (1.2 to 2.4)1.5 (1.0 to 2.2)
  >30.1274961.8 (1.2 to 2.6)1.9 (1.3 to 2.8)1.5 (1.0 to 2.3)
  • OR, odds ratio; 95% CI, 95% confidence interval; ref, reference; R, right; BMI, body mass index.

  • a Adjusted for age, sex, race, and site.

  • b Further adjusted for diabetes mellitus, systolic blood pressure, hypertension meds, albumin-to-creatinine ratio, smoking, LDL cholesterol, HDL cholesterol, oral estrogen, prevalent coronary heart disease, prevalent heart failure, and C-reactive protein. Kidney function decline was defined as eGFR-Cr decline >30% (using creatinine at years 3 and 10).