Table 1.

Characteristics of the CKD cohort and differences between patients with and without eGFR decline ≥30%

Characteristicn=1203eGFR Decline ≥30%, n=494No eGFR Decline ≥30%, n=709P Value
Demographics
 Women40.6 (489)37.9 (187)42.6 (302)0.11
 Age, yr65.9 SD 14.962.7 SD 15.168.2 SD 14.3<0.001
 Body mass index, kg/m230.1 SD 7.029.8 SD 6.730.3 SD 7.30.18
Cause of CKD<0.001
 Diabetes33.5 (403)41.1 (203)28.2 (200)
 Ischemic nephropathy18.7 (225)12.3 (61)23.1 (164)
 GN14.0 (168)18.8 (93)10.6 (75)
 Other33.8 (406)27.7 (137)38.1 (270)
Comorbidities
 Coronary artery disease33.2 (399)29.8 (147)35.5 (252)0.04
 Congestive heart failure27.3 (328)21.9 (108)31.0 (220)<0.001
 Hypertension92.8 (1116)94.7 (468)91.4 (648)0.03
 Peripheral vascular disease19.5 (234)18.8 (93)19.9 (141)0.66
 Hyperlipidemia73.9 (889)73.7 (364)74.0 (525)0.89
 Stroke13.8 (166)11.3 (56)15.5 (110)0.04
 Diabetes mellitus59.6 (717)59.1 (292)59.9 (425)0.81
 Cigarette smoker14.3 (172)15.2 (76)13.7 (96)0.45
 Malignancy14.4 (172)11.7 (58)16.1 (114)0.04
ACE/ARB51.9 (624)56.7 (280)48.5 (344)0.01
Laboratory
 Baseline eGFR, ml/min per 1.73 m216.8 SD 5.514.8 SD 4.018.2 SD 5.9<0.001
 Bicarbonate, mEq/L23.8 SD 4.523.4 SD 3.624.1 SD 5.00.03
 Albumin, g/dl3.6 SD 0.63.5 SD 0.63.6 SD 0.60.03
 Hemoglobin, g/L11.0 SD 1.611.1 SD 1.611.0 SD 1.60.06
 Potassium, mEq/L4.6 SD 0.64.6 SD 0.64.5 SD 0.60.06
 Phosphate, mg/dl4.3 SD 0.94.3 SD 0.94.3 SD 0.90.43
 Proteinuria categories<0.001
  Minimal24.3 (212)13.0(49)32.9 (163)
  Mild25.9 (226)34.5 (130)19.4 (96)
  Moderate25.9 (226)28.9 (109)23.6 (117)
  Severe25.9 (226)34.5 (130)19.4 (96)
Mean baseline SBP, mmHg139.2 SD 21.6141.1 SD 21.7136.0 SD 21.3<0.001
Distribution of baseline SBP (%, N)
 SBP≤12020.9 (234)17.3 (81)23.5 (153)0.001
 SBP 121–13935.6 (398)31.6 (148)38.4 (250)
 SBP≥14043.5 (487)51.1 (239)38.1 (248)
Mean SBP over time, mmHg134.7 SD 13.6137.8 SD 15.2134.4 SD 14.2<0.001
Mean baseline DBP, mmHg73.2 SD 12.675.2 SD 12.271.7 SD 12.8<0.001
Distribution of baseline DBP (%, N)
 DBP≤6017.5 (195)12.0 (56)21.4 (139)<0.001
 DBP 61–8972.6 (811)76.0 (355)70.2 (456)
 DBP≥909.9 (111)12.0 (56)8.5 (55)
Mean DBP over time, mmHg70.3 SD 7.972.5 SD 9.570.1 SD 9.0<0.001
Mean baseline PP, mmHg64.9 SD 19.465.9 SD 20.164.3 SD 18.80.18
Distribution of baseline PP (%, N)
 PP≤5026.4 (295)25.9 (121)26.8 (174)0.44
 PP 51–6935.5 (396)33.4 (156)36.9 (240)
 PP≥7038.1 (426)40.7 (190)36.3 (236)
Mean PP over time, mmHg64.4 SD 11.265.3 SD 15.664.3 SD 14.60.13
  • Values are presented as mean with SD or percentage and frequency. Missing total data (eGFR: 1.2%, SBP: 3.3%, DBP: 3.6%, PP: 3.6%, hemoglobin: 2.1%, potassium: 0.8%, bicarbonate: 5.1%, albumin: 6.4%, phosphate: 4.8%, and proteinuria: 19.2%). ACE/ARB, angiotensin-converting enzyme inhibitor/angiotensin receptor blocker; SBP, systolic BP; DBP, diastolic BP; PP, pulse pressure.