Table 6.

Association of measures of adiposity with incident CKD using eGFRcr

VariableNInc CKDRate (%/yr)Unadjusted
IRR (95% CI)Model 1a
IRR (95% CI)Model 2b
IRR (95% CI)
Subcutaneous fat
 Continuous (per SD=121)10554165.71.1 (1.0 to 1.1)1.0 (0.9 to 1.1)0.9 (0.9 to 1.0)
 Quartiles
  <1962601015.61.0 (ref)1.0 (ref)1.0 (ref)
  196–267259905.00.9 (0.7 to 1.1)0.9 (0.7 to 1.1)0.8 (0.7 to 1.0)
  268–3572791176.11.1 (0.9 to 1.3)1.0 (0.8 to 1.2)0.9 (0.8 to 1.2)
  >3572571086.11.1 (0.9 to 1.3)0.9 (0.7 to 1.2)0.9 (0.7 to 1.1)
Visceral fat
 Continuous (per SD=67)10554165.71.1 (1.0 to 1.2)1.0 (1.0 to 1.1)1.0 (0.9 to 1.1)
 Quartiles
  <94270904.81.0 (ref)1.0 (ref)1.0 (ref)
  94–1322751135.91.2 (1.0 to 1.5)1.2 (1.0 to 1.5)1.2 (1.0 to 1.5)
  133–1812631035.71.2 (0.9 to 1.5)1.1 (0.9 to 1.4)1.1 (0.9 to 1.3)
  >1812471106.41.3 (1.1 to 1.7)1.2 (0.9 to 1.5)1.1 (0.9 to 1.4)
R thigh intermuscular fat area (cm2)
 Continuous (per SD=6.8)10524155.71.1 (1.0 to 1.1)1.0 (0.9 to 1.1)1.0 (0.9 to 1.1)
 Quartiles
  <6.152941135.61.0 (ref)1.0 (ref)1.0 (ref)
  6.15–9.012921004.90.9 (0.7 to 1.1)0.9 (0.7 to 1.1)0.8 (0.7 to 1.0)
  9.02–13.122451166.81.2 (1.0 to 1.5)1.1 (0.9 to 1.3)1.1 (0.9 to 1.3)
  >13.12221865.61.0 (0.8 to 13)0.9 (0.7 to 1.1)0.9 (0.7 to 1.1)
Waist circumference
 Continuous (per SD=12.5)10554165.71.0 (1.0 to 1.1)1.0 (0.9 to 1.1)1.0 (0.9 to 1.1)
 Quartiles
  <91.72831165.91.0 (ref)1.0 (ref)1.0 (ref)
  91.7–99.2274904.70.8 (0.6 to 1.0)0.8 (0.6 to 1.0)0.8 (0.6 to 1.0)
  99.3–107.12631085.91.0 (0.8 to 1.2)1.0 (0.8 to 1.2)0.9 (0.8 to 1.1)
  >107.12351056.31.1 (0.9 to 1.3)0.9 (0.8 to 1.2)0.9 (0.7 to 1.1)
BMI
 Continuous (per SD=4.6)10554165.71.0 (1.0 to 1.1)1.0 (0.9 to 1.1)1.0 (0.9 to 1.1)
 Quartiles
  <24.1269935.01.0 (ref)1.0 (ref)1.0 (ref)
  24.1–26.82811145.81.2 (0.9 to 1.5)1.2 (1.0 to 1.5)1.2 (1.0 to 1.5)
  26.9–30.02691065.71.1 (0.9 to 1.4)1.1 (0.9 to 1.4)1.2 (0.9 to 1.4)
  >30.12361036.31.3 (1.0 to 1.6)1.2 (1.0 to 1.5)1.2 (0.9 to 1.5)
  • Incident CKD defined as eGFR-Cr<60 ml/min per 1.73 m2 at visit 10 and ΔeGFR-Cr>1ml/min per year among those with eGFR-Cr≥60 ml/min per 1.73 m2 at visit 3. Inc, incident; IRR, incident rate ratio; 95% CI, 95% confidence interval; ref, reference; R, right; BMI, body mass index.

  • a Adjusted for age, sex, race, site and baseline eGFR.

  • b Further adjusted for diabetes mellitus, systolic blood pressure, hypertension meds, albumin-to-creatinine ratio, smoking, LDL cholesterol, HDL cholesterol, oral estrogen, prevalent coronary heart disease, and prevalent heart failure.