Table 3.

The hazard ratios of categories of systolic BP, diastolic BP, and pulse pressure for eGFR decline ≥30% at the first clinic visit and time varying

BP Component, mmHgBaseline Unadjusted HR (95% CI)Baseline Adjusted HRa (95% CI)Time-Varying Unadjusted HR (95% CI)Time-Varying Adjusted HRb (95% CI)
Systolic BP (P=0.02c)
 <1050.84 (0.49 to 1.41)0.86 (0.51 to 1.46)1.28 (0.84 to 1.95)1.51 (0.98 to 2.34)
 105–1200.95 (0.69 to 1.31)1.02 (0.73 to 1.41)0.79 (0.58 to 1.05)0.85 (0.62 to 1.15)
 121–130ReferentReferentReferentReferent
 131–1401.10 (0.82 to 1.48)1.08 (0.81 to 1.46)1.12 (0.87 to 1.46)1.07 (0.81 to 1.41)
 141–1701.31 (1.01 to 1.70)1.24 (0.95 to 1.63)1.46 (1.15 to 1.84)1.14 (0.88 to 1.48)
 >1701.27 (0.88 to 1.84)1.19 (0.81 to 1.75)2.41 (1.62 to 3.60)1.62 (1.05 to 2.49)
Diastolic BP (P=0.05c)
 <500.47 (0.22 to 1.00)0.55 (0.26 to 1.17)0.89 (0.56 to 1.42)0.93 (0.57 to 1.52)
 51–600.77 (0.55 to 1.06)0.94 (0.67 to 1.31)1.06 (0.83 to 1.36)1.07 (0.83 to 1.39)
 61–70ReferentReferentReferentReferent
 71–801.04 (0.82 to 1.32)0.96 (0.76 to 1.23)1.21 (0.96 to 1.53)1.06 (0.82 to 1.37)
 81–901.25 (0.97 to 1.60)1.06 (0.81 to 1.40)1.67 (1.28 to 2.18)1.40 (0.99 to 1.86)
 >901.20 (0.84 to 1.72)0.91 (0.62 to 1.33)2.68 (1.87 to 3.82)1.83 (1.21 to 2.77)
Pulse pressure (P=0.80c)
 <351.13 (0.71 to 1.84)0.91 (0.56 to 1.49)1.30 (0.82 to 2.08)1.36 (0.83 to 2.24)
 36–501.05 (0.79 to 1.41)0.98 (0.73 to 1.31)1.03 (0.78 to 1.36)1.07 (0.79 to 1.44)
 51–60ReferentReferentReferentReferent
 60–751.06 (0.80 to 1.40)1.07 (0.80 to 1.41)1.15 (0.88 to 1.50)1.13 (0.85 to 1.50)
 76–1001.23 (0.94 to 1.63)1.24 (0.93 to 1.66)1.45 (1.11 to 1.88)1.19 (0.89 to 1.59)
 >1001.16 (0.73 to 1.84)1.30 (0.81 to 2.08)1.17 (0.69 to 1.97)1.09 (0.60 to 1.97)
  • HR, hazard ratio; 95% CI, 95% confidence interval.

  • a Data were adjusted for age, sex, cause of CKD, malignancy, coronary artery disease, congestive heart failure, peripheral vascular disease, diabetes mellitus, angiotensin-converting enzyme inhibitor/angiotensin receptor blocker use, and baseline measures of hemoglobin, bicarbonate, phosphate, potassium, albumin, and proteinuria. Number of events (GFR decline ≥30%) =494.

  • b Data were adjusted for age, sex, cause of CKD, malignancy, coronary artery disease, congestive heart failure, peripheral vascular disease, diabetes mellitus, angiotensin-converting enzyme inhibitor/angiotensin receptor blocker use, and time-updated measures of hemoglobin, bicarbonate, phosphate, potassium, albumin, and proteinuria.

  • c P value represents the association of each BP component over time modeled as a continuous variable.