Table 3.

ICD-10 diagnoses positively associated with HA-AKI

ICD-10DiagnosisOccurrencesP ValueOR (95% CI)
J80Adult respiratory distress syndrome12815×10−33016.8 (15 to 18.8)
N17Acute kidney failure55685×10−33015.9 (15 to 16.8)
R57Shock47775×10−33014.4 (13.5 to 15.3)
I46Cardiac arrest16335×10−33012.8 (11.5 to 14.1)
Z99Dependence on enabling machines and devices18005×10−3309.1 (8.2 to 10)
R40Somnolence, stupor, and coma19555×10−3309 (8.2 to 9.9)
J96Respiratory failure76725×10−3306 (5.7 to 6.4)
I50Heart failure88585×10−3304.8 (4.6 to 5.1)
N18CKD80855×10−3305.3 (4.9 to 5.7)
J15Bacterial pneumonia40814.4×10−3234.1 (3.9 to 4.4)
B96Other specified bacterial agents28714.8×10−2625.6 (5.2 to 6.1)
A41Other sepsis19481.4×10−2567.1 (6.5 to 7.9)
T81Complications of procedures, not elsewhere classified26812.7×10−1744.5 (4.1 to 5)
K72Hepatic failure6853.4×10−16711.4 (9.8 to 13.3)
B95Streptococcus and Staphylococcus as the cause of diseases15521.2×10−1646 (5.4 to 6.8)
I97Postprocedural disorders of the circulatory system9371.1×10−1498 (7 to 9.2)
R58Hemorrhage, not elsewhere classified10312.2×10−1417.1 (6.3 to 8.1)
D62Acute posthemorrhagic anemia17972.9×10−1374.9 (4.4 to 5.5)
I21Acute myocardial infarction20287.3×10−1274.4 (3.9 to 4.9)
N99Postprocedural disorders of the genitourinary system2951.1×10−12220.2 (16 to 25.4)
Y95Nosocomial condition5123.2×10−11210.3 (8.6 to 12.2)
Z49Care involving dialysis3863.4×10−11113.2 (10.8 to 16.2)
G93Other disorders of the brain5201.3×10−11010 (8.4 to 11.9)
J95Postprocedural respiratory disorders7914.9×10−1087.1 (6.1 to 8.2)
R34Anuria/oliguria3601.9×10−9412 (9.8 to 14.8)
D69Purpura and other hemorrhagic conditions10131.3×10−784.9 (4.2 to 5.6)
C64Malignant neoplasm of kidney, except renal pelvis8248.2×10−725.2 (4.4 to 6.1)
J69Pneumonitis due to solids and liquids9182.4×10−694.8 (4.1 to 5.5)
I31Other diseases of pericardium9395×10−684.7 (4 to 5.4)
K65Peritonitis7387.5×10−665.3 (4.5 to 6.2)
R41Other symptoms and signs involving cognitive functions and awareness10968.6×10−634.1 (3.5 to 4.7)
K55Vascular disorders of intestine7176.4×10−615.1 (4.3 to 6)
J81Complications of procedures2052.1×10−5311.7 (8.9 to 15.4)
D65Disseminated intravascular coagulation2171.1×10−4810.2 (7.8 to 13.3)
R39Other symptoms and signs involving the urinary system2054.1×10−4510 (7.5 to 13.2)
A40Streptococcal sepsis2775.8×10−417.2 (5.6 to 9.3)
R65Systemic inflammatory response syndrome4417.2×10−385 (4.1 to 6.2)
I33Endocarditis4061.4×10−365.2 (4.2 to 6.5)
J13Pneumonia due to Streptococcus pneumoniae4162.1×10−314.6 (3.7 to 5.8)
R45Symptoms and signs involving emotional state3646.1×10−294.8 (3.8 to 6)
I08Multiple valves disease4248.2×10−274.2 (3.3 to 5.2)
K26Duodenal ulcer3734.1×10−264.4 (3.5 to 5.6)
J85Abscess of lung and mediastinum2454.8×10−255.5 (4.2 to 7.3)
T79Certain early complications of trauma, not elsewhere classified2907.3×10−244.8 (3.7 to 6.3)
S35Injury of blood vessels at abdomen, lower back, and pelvis level1384.2×10−237.7 (5.4 to 11)
B37Candidiasis2971.6×10−224.6 (3.5 to 6)
J14Pneumonia due to Haemophilus influenzae2262.7×10−215.2 (3.9 to 7)
T68Hypothermia875.8×10−209.9 (6.5 to 15.2)
R68Other general symptoms and signs791.4×10−1810.1 (6.4 to 15.7)
D70Agranulocytosis1628.6×10−144.8 (3.3 to 6.8)
T86Failure and rejection of transplanted organs and tissues1203.2×10−135.5 (3.7 to 8.3)
G41Status epilepticus1924.7×10−134.2 (3 to 5.8)
I23Certain current complications following acute myocardial infarction772.2×10−127.2 (4.5 to 11.5)
N19Unspecified kidney failure1385×10−124.8 (3.2 to 7)
A48Other bacterial diseases, not elsewhere classified1021.5×10−115.6 (3.6 to 8.6)
R99Other ill-defined and unspecified causes of mortality994×10−115.5 (3.6 to 8.6)
S26Injury of heart901.1×10−105.7 (3.6 to 9)
M96Postprocedural musculoskeletal disorders, not elsewhere classified841.3×10−105.9 (3.7 to 9.5)
T46Poisoning by agents primarily affecting the cardiovascular system425.3×10−109.5 (5.1 to 17.7)
R98Unattended death762.9×10−95.7 (3.5 to 9.4)
M72Fibroblastic disorders796.5×10−95.4 (3.3 to 8.9)
J10Influenza with pneumonia, seasonal influenza virus identified891.4×10−84.9 (3 to 7.9)
G97Postprocedural disorders of nervous system, not elsewhere classified804.4×10−85 (3 to 8.2)
F99Mental disorder, not otherwise specified568.2×10−86.1 (3.5 to 10.8)
C65Malignant neoplasm of renal pelvis313.3×10−78.9 (4.3 to 18.3)
S33Dislocation, sprain, and strain of joints and ligaments of lumbar spine374.1×10−77.6 (3.9 to 14.9)
S25Injury of blood vessels of thorax881.1×10−64.1 (2.5 to 6.8)
X70Intentional self-harm by hanging, strangulation, and suffocation191.3×10−612.6 (5.1 to 31)
I22Subsequent myocardial infarction601.3×10−65.1 (2.9 to 9.1)
Y69Unspecified misadventure during surgical and medical care351.5×10−67.3 (3.6 to 14.7)
Y57Other and unspecified drugs and medicaments466.6×10−65.5 (2.9 to 10.5)
C66Malignant neoplasm of ureter582.1×10−54.5 (2.5 to 8.2)
S48Traumatic amputation of shoulder and upper arm113.3×10−516.7 (5.1 to 54.6)
  • Diagnoses significantly associated after correction for multiple comparisons (P value <3.3×10−5), and with an OR>4 are shown. Occurrence indicates the number of times an ICD-10 code was identified in the entire cohort (n=126,736 individuals). ORs were calculated as follows: in the whole population, ([ICD-10+/ICD-10−] in patients with HA-AKI) divided by ([ICD-10+/ICD-10−] in patients without HA-AKI). ICD-10, International Classification of Diseases–10; HA-AKI, hospital-acquired AKI; OR, odds ratio; 95% CI, 95% confidence interval..