Table 3.

Association of serum triglyceride/HDL cholesterol ratio with cardiovascular mortality, stratified by decile categories

TG/HDL-C LevelsUnadjustedCase-MixCase-Mix and MICSCase-Mix, MICS, and Statin
HR95% CIP ValueHR95% CIP ValueHR95% CIP ValueHR95% CIP Value
Baseline model
 <1.591.06(0.94 to 1.20)0.321.12(0.99 to 1.27)0.071.09(0.96 to 1.24)0.171.07(0.93 to 1.23)0.33
 1.59 to <2.100.98(0.86 to 1.11)0.740.99(0.87 to 1.12)0.860.95(0.84 to 1.08)0.450.90(0.78 to 1.03)0.13
 2.10 to <2.570.95(0.84 to 1.08)0.480.94(0.82 to 1.06)0.320.92(0.81 to 1.05)0.210.87(0.75 to 1.00)0.05
 2.57 to <3.081.07(0.95 to 1.21)0.281.06(0.93 to 1.20)0.401.04(0.91 to 1.17)0.591.06(0.92 to 1.21)0.44
 3.08 to <3.650.94(0.82 to 1.06)0.310.90(0.79 to 1.03)0.120.88(0.77 to 1.00)0.060.90(0.78 to 1.03)0.13
 3.65 to <4.321.001.001.001.00
 4.32 to <5.190.94(0.83 to 1.07)0.350.91(0.80 to 1.04)0.160.92(0.81 to 1.05)0.240.93(0.80 to 1.07)0.29
 5.19 to <6.430.85(0.74 to 0.97)0.010.84(0.74 to 0.96)0.010.87(0.76 to 0.99)0.040.84(0.73 to 0.98)0.02
 6.43 to <8.640.83(0.73 to 0.95)0.010.82(0.72 to 0.94)0.0030.84(0.73 to 0.96)0.010.85(0.73 to 0.98)0.03
 ≥8.640.76(0.67 to 0.87)<0.0010.79(0.69 to 0.91)0.0010.83(0.72 to 0.96)0.010.84(0.72 to 0.98)0.03
Time-varying model
 <1.381.10(0.97 to 1.25)0.121.21(1.07 to 1.37)0.0031.21(1.06 to 1.38)0.0041.19(1.03 to 1.37)0.02
 1.38 to <1.841.09(0.97 to 1.24)0.161.14(1.00 to 1.29)0.041.11(0.98 to 1.26)0.111.11(0.96 to 1.27)0.16
 1.84 to <2.291.13(1.00 to 1.28)0.061.15(1.01 to 1.30)0.031.10(0.96 to 1.24)0.161.08(0.94 to 1.24)0.30
 2.29 to <2.771.05(0.93 to 1.19)0.421.06(0.93 to 1.20)0.401.02(0.89 to 1.16)0.801.03(0.89 to 1.18)0.71
 2.77 to <3.331.00(0.88 to 1.14)0.971.01(0.88 to 1.14)0.940.98(0.86 to 1.11)0.740.97(0.84 to 1.12)0.70
 3.33 to <4.001.001.001.001.00
 4.00 to <4.890.92(0.81 to 1.05)0.230.93(0.82 to 1.06)0.290.96(0.84 to 1.09)0.520.88(0.76 to 1.02)0.10
 4.89 to <6.190.81(0.71 to 0.93)0.0020.82(0.72 to 0.94)0.0040.84(0.74 to 0.97)0.020.84(0.72 to 0.98)0.02
 6.19 to <8.590.81(0.71 to 0.93)0.0020.83(0.73 to 0.95)0.010.88(0.77 to 1.01)0.070.88(0.76 to 1.03)0.11
 ≥8.590.66(0.57 to 0.76)<0.0010.70(0.61 to 0.81)<0.0010.77(0.66 to 0.90)0.0010.78(0.66 to 0.92)0.004
  • Adjustments in case-mix model (n=48,728): age, sex, race/ethnicity, primary insurance, vascular access type, comorbid conditions, alcohol dependence, substance abuse, and single-pool Kt/V. Case-mix plus MICS model (n=47,185): case-mix adjusted model plus laboratory parameters including serum hemoglobin, white blood cell count, albumin, calcium, phosphorus, intact parathyroid hormone, bicarbonate, total iron binding capacity, ferritin, LDL cholesterol, and body mass index. Case-mix plus MICS plus statin model (n=42,605): statin therapy on the fully adjusted models. TG/HDL-C, triglyceride/HDL cholesterol ratio; MICS, malnutrition-inflammation-cachexia syndrome; HR, hazard ratio; 95% CI, 95% confidence interval.