Table 2.

Association of serum phosphorus levels at 1 yr after renal transplantation and covariates with overall mortality

ParametersUnivariateMultivariate
HR (95% CI)P ValueHR (95% CI)P Valuea
Serum phosphorus
<2.5 mg/dl (lowest)4.48 (1.42 to 14.12)0.014.82 (1.36 to 17.02)0.01
2.5–2.99 mg/dl1.49 (0.52 to 4.28)0.471.75 (0.54 to 5.62)0.35
3.0–3.49 mg/dl2.04 (0.95 to 4.39)0.072.19 (0.84 to 5.72)0.11
3.5–3.99 mg/dl1.0 (reference)0.161.0 (reference)0.29
4.0–4.49 mg/d1.77 (0.79 to 3.94)0.151.70 (0.64 to 4.53)0.31
4.5–4.99 mg/dl2.08 (0.77 to 5.63)0.0041.90 (0.55 to 6.59)0.04
≥5.0 mg/dl (highest)4.24 (1.07 to 16.84)4.24 (1.07 to 16.84)
Age (per 1 yr)1.07 (1.05 to 1.10)<0.0011.06 (1.03 to 1.10)<0.001
Men (versus women)1.08 (0.64 to 1.81)0.781.32 (0.69 to 2.54)0.40
Living donor (versus deceased)0.42 (0.25 to 0.69)<0.0010.62 (0.33 to 1.16)0.13
Donor age (per 1 yr)1.02 (0.99 to 1.04)0.121.01 (0.99 to 1.04)0.31
Diabetes (versus none)2.03 (1.21 to 3.42)0.011.07 (0.56 to 2.03)0.84
eGFR (per 1 ml/min per 1.73 m2)0.98 (0.96 to 0.99)0.011.00 (0.98 to 1.02)0.97
Albumin (per 1 g/dl)0.25 (0.17 to 0.35)<0.0010.40 (0.23 to 0.70)0.001
BMI (per 1 kg/m2)1.04 (0.95 to 1.13)0.370.97 (0.87 to 1.07)0.54
Hemoglobin (per 1 g/dl)0.81 (0.71 to 0.91)<0.0010.90 (0.76 to 1.07)0.24
T.Chol (per 1 mg/dl)0.99 (0.99 to 1.01)0.921.00 (0.99 to 1.01)0.38
Acute rejection (versus none)2.11 (1.26 to 3.53)0.0041.62 (0.87 to 3.01)0.13
  • The study population was classified into seven groups according to the level of serum phosphorus at 1 yr after transplantation with intervals of 0.5 mg/dl (lowest group, <2.5 mg/dl; highest group, ≥5.0 mg/dl; reference group, 3.5–3.99 mg/dl). HR, hazard ratio; 95% CI, 95% confidence interval; BMI, body mass index; T.Chol, total cholesterol.

  • a Multivariate Cox proportional hazard ratios, adjusted for recipient age and sex; donor type; donor age; diabetes mellitus; BMI; acute rejection; and eGFR, serum albumin, hemoglobin, and total cholesterol levels at 1 yr after transplantation.