Table 2.

Temporal trends in the renal biopsy frequencies of glomerular disease subtypes among the study cohort of patients with specified glomerular disease diagnoses

Glomerular disease subtype1986–1995, n=32571996–2005, n=79542006–2015, n=10,163Total, n=21,374
Nephrotic subtypes
 FSGS22.6 (737)27.2 (2165)24.7 (2506)25.3 (5408)
 Diabetic glomerulosclerosisa5.5 (179)11.4 (903)19.1 (1942)14.2 (3024)
 Membranous nephropathya17.8 (579)13.8 (1097)10.6 (1078)12.9 (2754)
 Minimal change diseasea8.8 (286)5.5 (441)4.1 (415)5.3 (1142)
 MPGNa4.5 (145)2.9 (233)2.5 (256)3.0 (634)
 Amyloidosis2.2 (73)2.0 (158)2.5 (252)2.3 (483)
 MIDDa0.6 (20)0.6 (51)1.6 (160)1.1 (231)
 Dense deposit disease0.3 (8)0.1 (9)0.2 (22)0.2 (39)
 Fabry diseaseb0.1 (3)0.1 (11)0.0 (2)0.1 (16)
 Collagenofibrotic glomerulopathy0.1 (2)0.0 (2)0.0 (1)0.0 (5)
 Total62.4 (2032)63.7 (5070)65.3 (6634)64.3 (13,736)
Nephritic subtypes
 Lupus nephritisa12.8 (416)13.9 (1109)11.2 (1142)12.5 (2667)
 IgANc10.2 (332)11.4 (908)9.4 (958)10.3 (2198)
 ANCA/pauci-immune GN9.3 (304)6.8 (540)8.3 (846)7.9 (1690)
 TBM lesiona1.9 (63)1.3 (101)3.0 (304)2.2 (468)
 Fibrillary GN1.5 (48)1.2 (99)1.4 (141)1.4 (288)
 Anti-GBM nephritisc1.1 (37)1.0 (82)0.8 (77)0.9 (196)
 Alport syndrome0.6 (20)0.4 (35)0.5 (50)0.5 (105)
 Immunotactoid GN0.2 (5)0.1 (10)0.1 (11)0.1 (26)
 Total37.6 (1225)36.3 (2884)34.7 (3529)35.7 (7638)
  • All values represent column percentages (n). MPGN, membranoproliferative GN (nondense deposit disease); MIDD, monoclonal immune deposition disease; IgAN, IgA nephropathy; TBM, thin basement membrane; GBM, glomerular basement membrane.

  • a Chi-squared test for trend, P<0.003.

  • b Fisher exact test, P<0.05 but P>0.003.

  • c Chi-squared test for trend, P<0.05 but P>0.003.