Table 3.

Association of serum phosphorus levels at 1 yr after renal transplantation and covariates with death-censored graft failure

ParametersUnivariateMultivariate
HR (95% CI)P ValueHR (95% CI)P Valuea
Serum phosphorus
<2.5 mg/dl (lowest)2.70 (1.20 to 6.08)0.023.32 (1.42 to 7.79)0.01
2.5–2.99 mg/dl2.07 (1.21 to 3.56)0.011.93 (1.03 to 3.62)0.04
3.0–3.49 mg/dl1.92 (1.24 to 2.96)0.0032.47 (1.47 to 4.15)<0.001
3.5–3.99 mg/dl1.0 (reference)<0.0011.0 (reference)<0.001
4.0–4.49 mg/dl2.09 (1.36 to 3.22)0.0042.37 (1.42 to 3.94)0.10
4.5–4.99 mg/dl2.24 (1.30 to 3.87)<0.0011.77 (0.89 to 3.52)0.01
≥ 5.0 mg/dl (highest)4.74 (2.60 to 8.67)2.93 (1.32 to 6.49)
Age (per 1 yr)1.01 (0.99 to 1.02)0.240.99 (0.98 to 1.01)0.38
Men (versus women)1.19 (0.89 to 1.60)0.251.87 (1.28 to 2.71)0.001
Living donor (versus deceased)0.59 (0.44 to 0.79)<0.0010.76 (0.52 to 1.09)0.13
Donor age (per 1 yr)1.01 (1.00 to 1.02)0.051.01 (0.99 to 1.02)0.31
Diabetes (versus none)1.29 (0.94 to 1.77)0.111.24 (0.86 to 1.79)0.26
eGFR (per 1 ml/min per 1.73 m2)0.97 (0.96 to 0.98)<0.0010.98 (0.97 to 0.99)<0.001
Albumin (per 1 g/dl)0.30 (0.23 to 0.41)<0.0010.29 (0.20 to 0.43)<0.001
BMI (per 1 kg/m2)1.03 (0.98 to 1.08)0.311.00 (0.95 to 1.06)0.96
Hemoglobin (per 1 g/dl)0.82 (0.77 to 0.88)<0.0010.91 (0.83 to 1.01)0.06
T.Chol (per 1 mg/dl)1.00 (0.99 to 1.01)0.691.01 (1.00 to 1.01)0.002
Acute rejection (versus none)4.57 (3.44 to 6.08)<0.0013.67 (2.62 to 5.15)<0.001
  • The study population was classified into seven groups according to the level of serum phosphorus at 1 yr after transplantation with intervals of 0.5 mg/dl (lowest group, <2.5 mg/dl; highest group, ≥5.0 mg/dl; reference group, 3.5–3.99 mg/dl). HR, hazard ratio; 95% CI, 95% confidence interval; BMI, body mass index; T.Chol, total cholesterol.

  • a Multivariate Cox proportional hazard ratios, adjusted for recipient age and sex; donor type; donor age; diabetes mellitus; BMI; acute rejection; and eGFR, serum albumin, hemoglobin, and total cholesterol levels at 1 year after transplantation.