Table 2.

Three-year cumulative incidence, incidence rate, hazard ratios, and subdistribution hazard ratios of a gout diagnosis presented by level of kidney function and sex

eGFR, ml/min per 1.73 m23-Year Cumulative Incidencea, % (95% CI)Incidence Rate per 1000 Person-Years (95% CI)Hazard Ratio (95% CI)Subdistribution Hazard Ratio (95% CI)a
UnadjustedAdjustedbUnadjustedAdjustedb
Women
 ≥90 (n=21,498)0.6 (0.5 to 0.7)2.0 (1.7 to 2.4)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)
 60–89 (n=93,576)0.7 (0.7 to 0.8)2.6 (2.4 to 2.8)1.3 (1.1 to 1.6)1.4 (1.1 to 1.7)1.3 (1.1 to 1.6)1.4 (1.2 to 1.7)
 45–59 (n=29,780)1.3 (1.2 to 1.4)4.6 (4.2 to 5.1)2.3 (1.9 to 2.9)2.1 (1.7 to 2.7)2.3 (1.9 to 2.8)2.3 (1.9 to 2.9)
 30–44 (n=13,424)2.2 (1.9 to 2.5)8.0 (7.1 to 8.9)4.0 (3.3 to 5.0)3.5 (2.7 to 4.4)3.8 (3.0 to 4.6)3.7 (2.9 to 4.7)
 15–29 (n=3378)3.4 (2.9 to 4.0)13.7 (11.3 to 16.3)7.0 (5.4 to 9.0)5.6 (4.2 to 7.4)6.0 (4.6 to 7.7)5.6 (4.2 to 7.5)
 Dialysis (n=2104)2.0 (1.5 to 2.8)8.9 (6.5 to 12.0)4.3 (1.8 to 10.5)3.1 (1.2 to 7.7)3.5 (2.5 to 4.9)2.8 (1.9 to 4.2)
Men
 ≥90 (n=15,318)0.8 (0.7 to 1.0)2.9 (2.4 to 3.4)1.0 (reference)1.0 (reference)1.0 (reference)1.0 (reference)
 60–89 (n=74,539)1.2 (1.1 to 1.3)4.3 (4.0 to 4.6)1.5 (1.2 to 1.8)1.6 (1.3 to 1.9)1.5 (1.3 to 1.8)1.6 (1.3 to 1.9)
 45–59 (n=18,244)2.5 (2.3 to 2.7)8.8 (8.0 to 9.7)3.1 (2.5 to 3.8)2.9 (2.3 to 3.6)3.0 (2.5 to 3.7)3.2 (2.6 to 3.9)
 30–44 (n=6816)3.7 (3.3 to 4.3)14.1 (12.4 to 15.9)5.0 (4.0 to 6.1)4.4 (3.5 to 5.5)4.6 (3.7 to 5.7)4.7 (3.7 to 5.9)
 15–29 (n=1824)4.6 (3.7 to 5.7)18.8 (15.1 to 23.1)6.7 (5.1 to 8.8)5.5 (4.1 to 7.4)5.7 (4.3 to 7.6)5.5 (4.1 to 7.4)
 Dialysis (n=2424)2.9 (2.3 to 3.6)13.1 (10.3 to 16.5)4.9 (2.0 to 12.0)3.6 (1.5 to 9.1)3.5 (2.6 to 4.7)3.1 (2.2 to 4.3)
  • 95% CI, 95% confidence interval.

  • a Estimates derived from the Fine and Gray method to account for the competing risk of death.

  • b Cox regression model looking at kidney function and gout, adjusted for age, diabetes, diuretic use, hypertension, and Charlson comorbidity index.