Table 3.

Linear regression models of variables associated with surrogate markers at study entry after stepwise variable selection

VariableLVMI, n=493cIMT SDS, n=510PWV SDS, n=513
β (95% CI)P Valueβ (95% CI)P Valueβ (95% CI)P Value
Intercept70.7 (61.3 to 80.1)<0.0010.58 (0.01 to 1.15)0.050.2 (−0.5 to 0.9)0.56
Age, yr−0.715 (−1.0 to −0.41)0.001−0.06 (−0.10 to −0.02)0.01
Girls−2.54 (−4.58 to −0.49)0.020.31 (0.05 to 0.57)0.02
Systolic BP (SDS)1.15 (0.43 to 1.88)<0.0010.22 (0.13 to 0.31)<0.0010.37 (0.26 to 0.48)<0.001
Physical activity >2 h/wk−3.94 (−5.95 to −1.93)0.0010.25 (0.00 to 0.5)0.04
BMI SDS1.43 (0.68 to 2.17)0.0010.08 (−0.13 to 0.17)0.09
HDL cholesterol, mg/dl−0.09 (−0.16 to −0.02)0.001
LDL cholesterol, mg/dl−0.03 (−0.06 to 0.00)0.02
Serum 25-OHD, ng/ml−0.01 (−0.02 to 0.00)0.004−0.01 (−0.24 to 0.00)0.01
eGFR, ml/min per 1.73 m2−0.22 (−0.32 to −0.13)<0.001
Serum albumin, g/L−0.20 (−0.37 to −0.04)0.07
Log urine albumin-to-creatinine ratio0.10 (0.02 to 0.18)0.01
Serum phosphorus, mmol/L0.72 (0.4 to 1.0)<0.001
iPTH, ng/ml0.01 (0.00 to 0.01)0.002
  • Supplemental Table 5 shows full models. LVMI, left ventricular mass index; cIMT, carotid intima-media thickness; SDS, SD score; PWV, pulse wave velocity; 95% CI, 95% confidence interval; —, no significant correlation for this variable; BMI, body mass index; 25-OHD, 25-hydroxy vitamin D; iPTH, immunoreactive parathyroid hormone.