Table 3.

Hospitalization events for HCV+ versus HCV− patients (DOPPS phases 1–5, 1996–2015)

Hospitalization TypeNo. of EventsCrude RateaUnadjusted HRb (95% CI)Adjusted HRc (95% CI)
All-cause hospitalization38,895626.71.06 (1.02 to 1.11)d1.09 (1.04 to 1.13)d
Cardiovasculare14,525187.21.04 (0.98 to 1.11)1.10 (1.03 to 1.17)d
 Stroke207423.30.97 (0.83 to 1.13)1.08 (0.92 to 1.27)
 Myocardial infarction220824.80.97 (0.82 to 1.15)1.05 (0.88 to 1.25)
Infectionf9597116.41.07 (0.99 to 1.16)1.08 (1.00 to 1.18)
 Sepsis259229.31.05 (0.89 to 1.23)1.06 (0.90 to 1.25)
 Pneumonia220924.91.14 (0.97 to 1.33)1.15 (0.98 to 1.35)
Hepatic-relatedg2312.65.51 (4.09 to 7.44)d4.40 (3.14 to 6.15)d
  • n=71,743 patients included in all-cause models. n=63,377 patients included in cause-specific models as large United States dialysis organizations in DOPPS phases 4 and 5 were excluded because of differential reporting of hospitalization cause. Facilities reporting zero hospitalizations during DOPPS follow-up or having <5 cumulative patient-years of hospitalization follow-up were excluded. HCV+, hepatitis C virus-positive; HCV−, hepatitis C virus-negative; DOPPS, Dialysis Outcomes and Practice Patterns Study; HR, hazard ratio; 95% CI, 95% confidence interval.

  • a First-hospitalization events (per 1000 patient years).

  • b Stratified by DOPPS country (United States black and nonblack patients considered as separate strata) and phase and accounting for facility clustering.

  • c Stratified by DOPPS country (United States black and nonblack patients considered as separate strata) and phase and accounting for facility clustering; adjusted for age, sex, time on dialysis, 13 summary comorbidities and hepatitis B infection, and albumin, phosphorus, and creatinine levels.

  • d P<0.05.

  • e Includes stroke and myocardial infarction among other cardiovascular-related hospitalizations.

  • f Includes sepsis and pneumonia among other infection-related hospitalizations.

  • g Includes hospitalizations with diagnosis of viral hepatitis or ascites, or liver biopsy procedure.