Table 1.

Characteristics of the Chronic Renal Insufficiency Cohort Study participants without heart failure by quartile of left ventricular mass index

CharacteristicLVMI Quartiles (N, g/m2.7)
641 (<41.3)643 (41.3 to <48.5)642 (48.5 to <57.5)641 (≥57.5)P ValueLinear Trend P Value
Age, yr58.0 [46.0, 64.0]60.0 [52.0, 66.0]61.0 [54.0, 67.0]62.0 [56.0, 67.0]<0.001<0.001
Sex
 Men327 (51.0%)345 (53.7%)365 (57%)341 (53.2)0.210.31
 Women314 (49%)298 (46.4%)277 (43.2%)300 (46.8%)
Race
 Non-Hispanic white393 (61.3%)305 (47.4%)255 (39.7%)164 (25.6%)<0.001<0.001
 Non-Hispanic black188 (29.3%)238 (37.%)267 (41.6%)314 (49%)
 Hispanic35 (5.5%)70 (10.9%)95 (14.8%)140 (21.8%)
 Other25 (3.9%)30 (4.7%)25 (3.9%)23 (3.6%)
Diabetes186 (29%)262 (40.8%)327 (50.9%)410 (64%)<0.001<0.001
History of hypertension480 (74.9%)548 (85.2%)591 (92.1%)624 (97.4%)<0.001<0.001
History of cardiovascular diseasea101 (15.8%)137 (21.3%)190 (29.6%)254 (39.6%)<0.001<0.001
Tobacco use74 (11.5%)69 (10.7%)76 (11.8%)81 (12.6%)0.760.27
Alcohol use457 (71.3%)396 (61.6%)383 (59.7%)310 (48.4%)<0.001<0.001
Systolic BP, mmHg117.2 (16.4)124.3 (19.1)128.8 (20.5)137.5 (24.6)<0.001<0.001
Diastolic BP, mmHg69.8 (10.9)70.2 (11.8)70.7 (12.9)71.8 (14.1)0.03<0.001
Body mass index, kg/m227.3 (5.1)30.1 (6.1)32.6 (6.4)35.6 (7.9)<0.001<0.001
Angiotensin–converting enzyme inhibitor or ARB414 (64.6%)431 (67%)460 (71.7%)455 (71.2%)0.020.01
Diuretics253 (39.5%)317 (49.3%)387 (60.3%)458 (71.7%)<0.001<0.001
β-Blockers196 (30.6%)266 (41.4%)314 (48.9%)398 (62.3%)<0.001<0.001
Aldosterone antagonists16 (2.50%)12 (1.9%)23 (3.6%)23 (3.6%)0.170.08
Aspirin220 (34%)267 (42%)297 (46%)315 (49%)<0.001<0.001
Statin322 (50%)355 (55%)374 (58%)422 (66%)<0.0010.08
Ejection fraction, %55.9 (6.1)55.8 (6.8)55.3 (7.0)53.6 (9.0)<0.001<0.001
Ln(24-h proteinuria)0.1 [0.1, 0.3]0.1 [0.1, 0.4]0.1 [0.1, 0.6]0.4 [0.1, 1.1]<0.001<0.001
eGFR, ml/min per 1.73 m249.9 (16.9)46.6 (17.1)41.8 (16.5)37.3 (14.5)<0.001<0.001
LDL, mg/dl103.9 (34.3)104.0 (35.4)101.0 (34.3)97.2 (35.1)0.001<0.001
HDL, mg/dl53.2 (17.9)50.0 (15.1)47.3 (15.6)45.1 (13.0)<0.001<0.001
Calcium, mg/dl9.4 (0.5)9.4 (0.5)9.3 (0.5)9.2 (0.6)<0.001<0.001
Phosphate, mg/dl3.6 (0.6)3.7 (0.6)3.7 (0.6)3.9 (0.7)<0.001<0.001
Hemoglobin, mg/dl13.5 (1.6)13.0 (1.7)12.8 (1.7)12.1 (1.8)<0.001<0.001
PTH, pg/ml48.0 [33.7, 70.3]54.1 [36.0, 85.0]58.0 [39.5, 97.0]74.7 [47.9, 120.0]<0.001<0.001
FGF23, RU/ml107.0 [75.6, 164.6]124.0 [84.7, 194.3]134.5 [92.7, 208.3]167.7 [109.9, 280.0]<0.001<0.001
BNP, pg/ml23.6 [7.6, 51.5]30.5 [12.8, 65.3]38.1 [16.4, 85.9]59.5 [22.4, 125.2]<0.001<0.001
Troponin T, pg/ml6.3 [1.5, 11.5]8.6 [4.4, 16.1]12.2 [6.1, 21.1]17.5 [9.7, 32.6]<0.001<0.001
  • Entries in first four columns are number (percent) or mean [range]. P value by chi-squared test for categorical variables or ANOVA for continuous variables. LVMI, left ventricular mass index; ARB, angiotensin receptor blocker; PTH, parathyroid hormone; FGF23, fibroblast growth factor-23; BNP, B–type natriuretic peptide.

  • a Coronary artery disease, peripheral vascular disease, or stroke.