Table 4.

Univariate- and multivariable-adjusted logistic regression models for in-hospital mortality

CovariateUnadjusted OR (95% CI)P ValueMultivariable-Adjusted OR (95% CI)P Value
Adherence versus nonadherence
 Higher disease severitya1.09 (0.40 to 2.95)0.861.06 (0.38 to 2.95)b0.91
 Lower disease severitya0.22 (0.09 to 0.55)0.0010.21 (0.08 to 0.54)b0.001
Age at enrollment1.02 (1.00 to 1.04)0.121.02 (1.00 to 1.04)0.10
Albumin at enrollment0.49 (0.29 to 0.82)<0.010.49 (0.27 to 0.89)0.02
  • Adherence versus nonadherence refers to whether physicians implemented the recommendation regarding initiation of RRT; prespecified subgroups were higher– versus lower–risk disease severity. OR, odds ratio; 95% CI, 95% confidence interval.

  • a Higher disease severity indicates >50% predicted risk of mortality. Lower disease severity indicates ≤50% predicted risk of mortality.

  • b Model incorporates an interaction term between risk group and adherence; interaction term of disease severity and adherence, P=0.02.